We performed a complex functional study of the effects of prostaglandin synthesis blockage with diclofenac on manifestation of the hydroosmotic effect of vasopressin V2-receptor agonist desmopressin in the kidneys of Wistar rats with normal synthesis of endogenous vasopressin and homozygous Brattleboro rats with hereditary impaired synthesis of neurohypophyseal hormone vasopressin. Blockage of prostaglandin synthesis led to more pronounced increase in urine osmolality in Brattleboro rats than in Wistar rats due to elevation of not only urine but also sodium gradient at the expense of elimination of the inhibitory effect of prostaglandins on sodium reabsorption and membrane permeability for urine. During combined treatment, the effects of the hormone predominated: the increase in urine osmolality in Wistar and Brattleboro rats did not differ from that after desmopressin administration.
Similar content being viewed by others
References
Natochin IV, Prutskova NP, Shakhmatova EI. Increase of water permeability and recovery of water impermeability of the frog urinary bladder. Ross. Fiziol. Zh. 2001;87(8):1095-1105. Russian.
Parnova RG. Molecular mechanisms of prostaglandin E2 action in the regulation of water osmotic permeability. Biol. Membrany. 1999;16(2):230-241. Russian.
Harris RC, Breyer MD. Physiological regulation of cyclooxygenase-2 in the kidney. Am. J. Physiol. Renal Physiol. 2001;281(1):F1-F11.
Lavrinenko VA, Babina AV. Analysis of the effi ciency of osmotic concentration in Wistar and Brattleboro rats under the effect of desmopressin. Bull. Exp. Biol. Med. 2014;156(5):624-626.
Lavrinenko VA, Babina AV, Shestopalova LV, Beizel NF, Ivanova LN. Effects of sodium diclofenac on the concentration function in animals with different neurohypophyseal status. Bull. Exp. Biol. Med. 2012;152(6):728-730.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 148-151, August, 2016
Rights and permissions
About this article
Cite this article
Lavrinenko, V.A., Babina, A.V. Efficiency of Osmotic Concentration after Combined Treatment with Vasopressin and Blockage of Prostaglandin Synthesis. Bull Exp Biol Med 162, 187–190 (2016). https://doi.org/10.1007/s10517-016-3572-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-016-3572-2