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Untersuchungen an wachen Hunden über die Einstellung der Natriumbilanz

II. Postprandiale Elektrolyt- und Wasserbilanz bei unterschiedlicher Kochsalzzufuhr

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Summary

Sodium and potassium excretion, GFR (inulin clearance), ECF (inulin space) and TRBF (electromagnetic flowmeter) were determined in trained dogs 3 hrs after feeding either sodium poor (0.5 mEq/kg) or sodium rich (14 mEq/kg) meals.

Low and high ECF's were induced by 1–4 months of low and high salt feeding, respectively. The animals could be divided into two groups according to prior dietary history.

1. 3 hrs after sodium rich meals animals with low ECF showed a delayed Na excretion (15% of Na load) whereas animals with high ECF excreted Na at high rates (30% of Na load) in the postprandial phase. The latter group received a low sodium diet a few days before the experimental period. This low sodium period was needed in order to make the two groups comparable.

2. The postprandial potassium excretion was augmented in both groups, independently of the size of the ECF prior to the experiment.

3. The postprandial ECF increased independently of dietary history or salt content of meals. However, the extent of increase was less after the salt poor meal (+12.7%) than after the salt rich meal (+25.5%).

4. GFR also increased postprandially. The maximum, observed on the first day of the salt rich period, amounted to 165% of the preprandial value. It returned progressively during the salt rich period to the value seen in dogs with salt poor diet (131%). The return was accompanied by increased sodium excretion. Hence, no direct correlation between GFR and sodium excretion was found in these experiments.

5. TRBF increased postprandially up to 160% of the value of the fasting animal, independently of dietary history and salt content of meals.

6. Calculations of Na distribution revealed 20–144 mEq in the intracellular space in the third postprandial hour. A comparable amount of potassium was lost from this space. If a similar shift in renal cells occurs, then content of sodium within renal cells may be a regulatory factor in Na excretion.

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  1. Physiologisches Institut der Universität München, Germany

    D. W. Behrenbeck & H. W. Reinhardt

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Behrenbeck, D.W., Reinhardt, H.W. Untersuchungen an wachen Hunden über die Einstellung der Natriumbilanz. Pflügers Arch 295, 280–292 (1967). https://doi.org/10.1007/BF01844107

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  • DOI: https://doi.org/10.1007/BF01844107

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