Skip to main content
SpringerLink
Log in

Vagal reflex inhibition of motility in the abomasal body of sheep by antral and duodenal tension receptors

  • Physiology
  • Published:
Veterinary Research Communications Aims and scope Submit manuscript

Abstract

Vagally-mediated regulation of motility in the abomasal body by duodenal and abomasal antral motility was demonstrated in acutely prepared anaesthetized sheep. The enteric plexuses between the abomasal body, antrum and duodenum were interrupted by transection. Antral contractions were more effective than duodenal contractions at causing inhibition of the abomasal body, and antral isometric conditions were more effective than antral isotonic conditions. Inhibition of motility in the abomasal body was reduced by unilateral cervical vagotomy, was abolished by bilateral cervical vagotomy, and was reversibly inhibited by cervical vagus cold block. The demonstration of vagal pathways in abomaso-abomasal reflexes confirms a functional homology of the mechanisms in the ruminant and animals with simple forms of stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

b-t:

balloon-tipped

EMG:

electromyography

NANC:

non-adrenergic, non-cholinergic

o-t:

open-tipped

References

  • Abrahamsson, H., 1973a. Vagal relaxation of the stomach induced from the gastric antrum.Acta Physiologica Scandinavica,89, 406–414

    PubMed  Google Scholar 

  • Abrahamsson, H., 1973b. Studies on the inhibitory nervous control of gastric motility.Acta Physiologica Scandinavica,Supplement 390, 1–38

    Google Scholar 

  • Abrahamsson, H., 1974. Reflex adrenergic inhibition of gastric motility elicited by the gastric antrum.Acta Physiologica Scandinavica,90, 14–24

    PubMed  Google Scholar 

  • Abrahamsson, H. and Jansson, G., 1973. Vago-vagal gastro-gastric relaxation in the cat.Acta Physiologica Scandinavica,88, 289–295

    PubMed  Google Scholar 

  • Abrahamsson, H., Glise, H. and Glise, K., 1979. Reflex suppression of gastric motility during laparotomy and gastroduodenal nociceptive stimulation.Scandinavian Journal of Gastroenterology,14, 101–106

    PubMed  Google Scholar 

  • Andrews, P.L.R. and Lawes, I.N.C., 1985. Characteristics of the vagally driven non-adrenergic inhibitory innervation of ferret gastric corpus.Journal of Physiology,363, 1–20

    PubMed  Google Scholar 

  • Andrews, P.L.R. and Wood, K.L., 1984. The effect of chemical and mechanical stimuli applied to the gastric antral mucosa on corpus motility in the anaesthetized ferret.Journal of Physiology,348, 63P

    Google Scholar 

  • Andrews, P.L.R., Grundy, D. and Lawes, I.N.C., 1980. The role of the vagus and splanchnic nerves in the regulation of intragastric pressure in the ferret.Journal of Physiology,307, 401–411

    PubMed  Google Scholar 

  • Bell, F.R., 1978. The pressure relationship in the gastric body, antrum and duodenum during gastric (abomasal) emptying in the calf. In: H.L. Duthie (ed.),Gastrointestinal Motility in Health and Disease, (MTP Press, Lancaster), 485–493

    Google Scholar 

  • Bell, F.R. and Grivel, M.-L., 1975. The effect of duodenal infusion on the electromyogram of gastric muscle during activation and inhibition of gastric emptying.Journal of Physiology,248, 377–391

    PubMed  Google Scholar 

  • Bell, F.R. and Watson, D.J., 1976. The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf.Journal of Physiology,259, 445–456

    PubMed  Google Scholar 

  • Bell, F.R., Green, A.R., Wass, J.A.H. and Webber, D.E., 1981. Intestinal control of gastric function in the calf: the relationship of neural and endocrine factors.Journal of Physiology,321, 603–610

    PubMed  Google Scholar 

  • Bueno, L. and Fioramonti, J., 1980. Rhythms of abomaso-intestinal motility. In: Y. Ruckebusch and P. Thivend (eds.),Digestive Physiology and Metabolism in Ruminants, (MTP Press, Lancaster), 53–80

    Google Scholar 

  • Cottrell, D.F. and Gregory, P.C., 1991. Regulation of gut motility by luminal stimuli in the ruminant. In:Physiological Aspects of Digestion and Metabolism in Ruminants, Proceedings of the 7th International Symposium on Ruminant Physiology, (Academic Press, London), 3–32

    Google Scholar 

  • Cottrell, D.F. and Iggo, A., 1984. Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep.Journal of Physiology,354, 457–475

    PubMed  Google Scholar 

  • Cottrell, D.F. and Reynolds, G.W., 1994. Electrophysiological characteristics of tension receptors in the abomasal antrum of sheep.Veterinary Research Communications,18, 225–238

    PubMed  Google Scholar 

  • Cottrell, D.F. and Stanley, H.G., 1992. An excitatory body-antral reflex in the sheep abomasum.Experimental Physiology,77, 565–574

    PubMed  Google Scholar 

  • Deloof, S. and Rousseau, J.P., 1985. Neural control of electrical gastric activity in response to inflation of the antrum in the rabbit.Journal of Physiology,367, 13–25

    PubMed  Google Scholar 

  • Deloof, S., Croix, D. and Tramu, G., 1988. The role of vasoactive intestinal polypeptide in the inhibition of antral and pyloric electrical activity in rabbits.Journal of the Autonomic Nervous System,22, 167–173

    PubMed  Google Scholar 

  • Gleysteen, J.J., Esser, M.J. and Myrvik, A.L., 1983. Reversible truncal vagotomy in conscious dogs.Gastroenterology,85, 578–583

    PubMed  Google Scholar 

  • Gregory, P.C., 1987. Inhibition of reticulo-ruminal motility by volatile fatty acids and lactic acid in sheep.Journal of Physiology,382, 355–371

    PubMed  Google Scholar 

  • Grundy, D., Hutson, D. and Scratcherd, T., 1986. A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret.Journal of Physiology,381, 377–384

    PubMed  Google Scholar 

  • Grundy, D., Hutson, D., Rudge, L.J. and Scratcherd, T., 1989. Pre-pyloric mechanisms regulating gastric motor function in the conscious dog.Quarterly Journal of Experimental Physiology,74, 857–865

    PubMed  Google Scholar 

  • Harding, R. and Leek, B.F., 1972. Gastro-duodenal receptor responses to chemical and mechanical stimuli, investigated by a ‘single fibre’ technique.Journal of Physiology,222, 139–140P

    Google Scholar 

  • Iggo, A., 1955. Tension receptors in the stomach and the urinary bladder.Journal of Physiology,128, 593–607

    PubMed  Google Scholar 

  • Kametani, H., Sato, A., Sato, Y. and Simpson, A., 1979. Neural mechanisms of reflex facilitation and inhibition of gastric motility to stimulation of various skin areas in rats.Journal of Physiology,294, 407–418

    PubMed  Google Scholar 

  • Leek, B.F. and Harding, R., 1975. Sensory nervous receptors in the ruminant stomach and the reflex control of reticulo-ruminal motility. In: I.W. McDonald and A.C.I. Warner (eds.),Digestion and Metabolism in the Ruminant, (The University of New England Press)

  • Li, C.G. and Rand, M.J., 1990. Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus.European Journal of Pharmacology,191, 303–309

    PubMed  Google Scholar 

  • Phillipson, A.T., 1952. The passage of digesta from the abomasum of sheep.Journal of Physiology,116, 84–97

    PubMed  Google Scholar 

  • Reynolds, G.W., Simpson, H.V., Carr, D.H. and McLeay, L.M., 1991. Gastrin: its molecular forms and secretion in sheep. In; T. Tsuda, Y. Sasaki and R. Kawashima (eds.),Physiological Aspects of Digestion and Metabolism in Ruminants, Proceedings of the 7th International Symposium on Ruminant Physiology, (Academic Press, London), 63–87

    Google Scholar 

  • Ruckebusch, Y., 1976. Interaction of duodenal and antral activity in sheep and dogs.Journal of Physiology,254, 79–80P

    Google Scholar 

  • Ruckebusch, Y., Grivel, M.-L. and Santini, R., 1968. Technique de derivation chronique de l'activité electrique et mecanique du tractus digestif chez l'animal eveille.Comparative Veterinary Medicine and Science, Lyon,70, 337–345

    Google Scholar 

  • Thomas, J.E., 1957. Mechanics and regulation of gastric emptying.Physiological Reviews,37, 453–474

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, EH9 1QH, Edinburgh, UK

    D. F. Cottrell

Authors
  1. D. F. Cottrell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cottrell, D.F. Vagal reflex inhibition of motility in the abomasal body of sheep by antral and duodenal tension receptors. Vet Res Commun 18, 319–330 (1994). https://doi.org/10.1007/BF01839200

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01839200

Keywords

Search

Navigation