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Citrate and urease-induced crystallization in synthetic and human urine

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Summary

The effects of citrate on the different phases of urease-induced crystallization were studied using Coulter counter techniques and optical microscopy. Citrate increased urine pH and markedly delayed the initiation of the crystallization (nucleation) in both human and synthetic urine. In synthetic urine, particle aggregation and espicially particle growth were delayed and inhibited by citrate. In human urine, aggregation was distinctly inhibited by citrate. It appears that the susceptibility of urine to form crystals in the precense of urease activity is influenced by its citrate concentration.

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Authors and Affiliations

  1. Department of Urology, Sahlgrenska sjukhuset, University of Göteborg, S-41345, Göteborg, Sweden

    Yu-hui Wang, Lars Grenabo, Hans Hedelin & Silas Pettersson

  2. Department of Urology, Queen's University, K7L 3N6, Kingston, Ontario, Canada

    Robert J. C. McLean & J. Curtis Nickel

  3. Department of Microbiology and Immunology, Queen's University, K7L 3N6, Kingston, Ontario, Canada

    Robert J. C. McLean

Authors
  1. Yu-hui Wang
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  2. Lars Grenabo
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  3. Hans Hedelin
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  4. Robert J. C. McLean
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  5. J. Curtis Nickel
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  6. Silas Pettersson
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Wang, Yh., Grenabo, L., Hedelin, H. et al. Citrate and urease-induced crystallization in synthetic and human urine. Urol. Res. 21, 109–115 (1993). https://doi.org/10.1007/BF01788828

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  • DOI: https://doi.org/10.1007/BF01788828

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