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Transmembrane Ca2+ gradient and function of membrane proteins

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Bioscience Reports

Abstract

This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca2+-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca2+-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.

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Abbreviations

Cai :

Ca2+ inside vesicles

Ca0 :

Ca2+ outside vesicles

SR:

sarcoplasmic reticulum

PC:

phosphatidylcholine

PS:

phosphatidylserine

PG:

phosphatidylglycerol

PE:

phosphatidylethanolamine

DPH:

1,6-diphenyl-1,3,5-hexatriene

n-AS:

n-(9-anthroyloxy) fatty acids

TMA-DPH:

1-(4-trimethylammoniumphenyl)-6)-phenyl-1,3,5-hexatriene

FCCP:

carbonylcyanide-p-trifluoromethoxyphenylhydrazone

β-AR:

β-adrenergic receptors

DHA:

dihydroalprenolol

AC:

adenylate cyclase

AC·Lca+−:

higher Ca2+ inside vesicles

AC·Lca− −:

lower Ca2+ on both side of vesicles

AC·Lca++:

higher Ca2+ on both side of vesicles

AC·Lca− +:

higher Ca2+ outside vesicles

cAMP:

cyclic adenosine monophosphate

Gs:

stimulatory GTP-binding protein

GTP:

guanosine triposphate

GTPγS:

guanosine 5′0-(3-thiotriphosphate)

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Authors and Affiliations

  1. National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, 100101, Beijing, China

    F. Y. Yang, Y. G. Huang & Y. P. Tu

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  1. F. Y. Yang
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  2. Y. G. Huang
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  3. Y. P. Tu
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Yang, F.Y., Huang, Y.G. & Tu, Y.P. Transmembrane Ca2+ gradient and function of membrane proteins. Biosci Rep 15, 351–364 (1995). https://doi.org/10.1007/BF01788367

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