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Inhibition of electron transport enzymes and cholinesterases by Endrin

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Summary

Two enzymes involved in mitqchondrial electron transport in the catfish,Ictalurus melas, have been shown to be inhibited by endrin. Succinate dehydrogenase and cytochrome oxidase were both inhibited, and the extent of inhibition depended ypon endrin concentration and the specific activity ef the enzyme preparation. No appreciable effect of endrin on acetylcholinesterase or NADH-cytochrome c reductase was seen. Binding to lipoprotein components essential for mitochondrial oxidation has been proposed as a logical site for endrin action.

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Author notes

  1. H. J. Colvin

    Present address: Dept. of Microbiology, Louisiana State University, Baton Rouge, La.

  2. A. T. Phillips

    Present address: Dept. of Biochemistry, Pennsylvania State University, University Park, Pa.

Authors and Affiliations

  1. Department of Biochemistry, Louisiana State University, Baton Rouge, Louisiana

    H. J. Colvin & A. T. Phillips

Authors
  1. H. J. Colvin
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  2. A. T. Phillips
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Colvin, H.J., Phillips, A.T. Inhibition of electron transport enzymes and cholinesterases by Endrin. Bull. Environ. Contam. Toxicol. 3, 106–115 (1968). https://doi.org/10.1007/BF01723732

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  • DOI: https://doi.org/10.1007/BF01723732

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