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Sequence and transcriptional analysis of an orf virus gene encoding ankyrinlike repeat sequences

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Abstract

A 1608 bp region located approximately 5.0 kb from the left end of the orf virus (OV) genome (strain NZ2) was sequenced. The sequence revealed a single open reading frame designated G1L. The predicted amino acid sequence of G1L contained eight ankyrinlike repeat sequences. Transcriptional analysis of G1L showed it was transcribed towards the genome terminus during the early phase of infection. S1 nuclease and primer extension analyses showed that the transcriptional start site of the gene was located a short distance downstream from an A+T-rich sequence similar to a vaccinia virus early promoter.

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References

  1. Mercer A.A., Fraser K.F., Barnes G., and Robinson A.J., Virology157 1–12, 1987.

    Google Scholar 

  2. Fraser K.M., Hill D.F., Mercer A.A., and Robinson A.J., Virology176 379–389, 1990.

    Google Scholar 

  3. Cochran M.A., Puckett C., and Moss B.J., Virology54 30–37, 1985.

    Google Scholar 

  4. Plucienniczak A., Schroeder E., Zettelmeissl G., and Streeck R.E., Nucleic Acids Res13 958–998, 1985.

    Google Scholar 

  5. Mars M. and Beaud G.J., Mol Biol198 619–631, 1987.

    Google Scholar 

  6. Vassef A., Nucleic Acids Res15 1427–1443, 1987.

    Google Scholar 

  7. Davison A.J. and Moss B.J., Mol Biol210 749–769, 1989.

    Google Scholar 

  8. Fleming S.B., Fraser K.M., Mercer A.A., and Robinson A.J., Gene97 207–212, 1991.

    Google Scholar 

  9. Fleming S.B., Mercer A.A., Fraser K.M., Lyttle D.J., and Robinson A.J., Virology187 464–471, 1992.

    Google Scholar 

  10. Fleming S.B., Blok J., Fraser K.M., Mercer A.A., and Robinson A.J., Virology195 175–184, 1993.

    Google Scholar 

  11. Rohrmann G, Yuen L., and Moss B., Cell46 1029–1035, 1986.

    Google Scholar 

  12. Yuen L. and Moss B., Proc Natl Acad Sci USA84 6417–6421, 1987.

    Google Scholar 

  13. Lee-Chen G.J., Bougeois N., Davidson K., Condit R.C., and Niles E.G., Virology163 64–79, 1988.

    Google Scholar 

  14. Rhim J.S., Cho H.Y., and Huebner R.J., Int J Cancer15 23–29, 1975.

    Google Scholar 

  15. Balassu T.C. and Robinson A.J., Arch Virol97 267–278, 1987.

    Google Scholar 

  16. Altshul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J., J Mol Biol215 403–410, 1990.

    Google Scholar 

  17. Pearson W.R. and Lipman D.J., Proc Natl Acad Sci USA85 2444–2448, 1988.

    Google Scholar 

  18. Breeden L. and Nasmyth K., Nature329 651–654, 1987.

    Google Scholar 

  19. Lux S.E., John K.M., and Bennett V., Nature344 36–42, 1990.

    Google Scholar 

  20. Roehl H. and Kimble J., Nature364 632–635, 1993.

    Google Scholar 

  21. Lemarco K., Thompson C.T., Byers B.P., Walton E.M., and McKnight S.L., Science253 789–792, 1991.

    Google Scholar 

  22. Ghosh S., Gifford A.M., Riviere L.R., Tempst P., Nolan G.P., and Baltimore D., Cell62 1019–1029, 1990.

    Google Scholar 

  23. Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., Le Bail O., Urban B.M., Kourilsky P., Baeuerle P.A., and Israel A., Cell62 1007–1018, 1990.

    Google Scholar 

  24. Blank V., Kourilsky P., and Israel A., Trends Biolo Sci17 135–140, 1992.

    Google Scholar 

  25. Schmid R.M., Perkins M.D., Duckett C.S., Andrews P.C., and Nabel J.G., Nature352 733–736, 1991.

    Google Scholar 

  26. Haskill S., Beg A.A., Tompkins M.S., Morris J.S., Yurochko A.D., Sampson-Johannes A., Mondal K., Ralph P., and Baldwin A.S. Jr., Cell65 1281–1289, 1991.

    Google Scholar 

  27. Franzosos G., Bours V., Park S., Tomita-Yamaguchi M., and Siebelist U., Nature359 339–342, 1992.

    Google Scholar 

  28. Davis N., Ghosh S., Simmons D.L., Tempst P., Liou H.-C., Baltimore D., and Bose H.R. Jr., Science253 1286–1271, 1991.

    Google Scholar 

  29. Inoue J.-I., Kerr L.D., Rashid D., Davis N., Bose H.R. Jr., and Verma I.M., Proc Natl Acad Sci USA89 4333–433, 1992.

    Google Scholar 

  30. Milner C.M. and Cambell R.D., Biochem J290 811–818, 1993.

    Google Scholar 

  31. Yochem J. and Greenwald I., Cell58 553–563, 1988.

    Google Scholar 

  32. Coffman C., Harris W., and Kintner C., Science249 1438–1441, 1990.

    Google Scholar 

  33. Spence A.M., Coulson A., and Hodgkin J., Cell60 981–990, 1990.

    Google Scholar 

  34. Ellisen L.W., Bird J., West D.C., Soreng A.L., Reynolds T.C., Smith S.D., and Sklar J., Cell66 649–661, 1991.

    Google Scholar 

  35. Wharton K.A., Johansen K.M., Xu T., and Artavanis-Tsakonas S., Cell43 567–581, 1985.

    Google Scholar 

  36. Brendel V., Bucher P., Nourbakhsh I., Blaisdell B.E., and Karlin S., Proc Natl Acad Sci USA89 2002–2006, 1992.

    Google Scholar 

  37. Hatada E.N., Nieters A., Wulczyn G.F., Naumann M., Meyer R., Nucifora G., McKeithan T.W., and Scheidereit C., Proc Natl Acad Sci USA89 2489–2493, 1992.

    Google Scholar 

  38. Drillien R., Koehren F., and Kirn A., Virology111 488–499, 1981.

    Google Scholar 

  39. Gillard S., Spehner D., Drillien R., and Kirn A., Proc Natl Acad Sci USA83 5573–5577, 1986.

    Google Scholar 

  40. Spehner D., Gillard S., Drillien R., and Kirn, A., J Virol62 1297–1304, 1988.

    Google Scholar 

  41. Perkus M.E., Goebel S.J., Davis S.W., Johnson G.P., Limbach K., Norton E.K., and Paoletti E., Virology179 276–286, 1990.

    Google Scholar 

  42. Bloom D.C., Edwards K.M., Hager C., and Moyer R.W., J Virol65 1530–1542, 1991.

    Google Scholar 

  43. Massung R.F., McFadden G., and Moyer R.W., J Gen Virol73 2903–2921, 1992.

    Google Scholar 

  44. Mercer A.A., Fraser K.M., Stockwell P.A., and Robinson A.J., Virology172 665–668, 1989.

    Google Scholar 

  45. Davis L.H. and Bennet V.J., Biol Chem265 10589–10596, 1990.

    Google Scholar 

  46. Thompson C.T., Brown T.A., and McKnight S.L., Science253 762–768, 1991.

    Google Scholar 

  47. Wulczyn G.F., Naumann M., and Scheidereit C., Nature358 597–599, 1992.

    Google Scholar 

  48. Howard S.T., Chan Y.S., and Smith G.L., Virology180 633–647, 1991.

    Google Scholar 

  49. Berk A.J. and Sharp P.A., Cell12 721–732, 1977.

    Google Scholar 

  50. McKnight S.L., Gavis E.R., Kingsbury R., and Axel R., Cell25 385–398, 1981.

    Google Scholar 

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Author notes

  1. Anthony J. Robinson

    Present address: CSIRO Division of Wildlife and Ecology, P.O. Box 84, 2602, Lyneham, ACT, Australia

Authors and Affiliations

  1. Health Research Council Virus Research Unit and Centre for Gene Research, University of Otago, Dunedin, New Zealand

    John T. Sullivan, Kate M. Fraser, Stephen B. Fleming, Anthony J. Robinson &  Andrew A. Mercer

Authors
  1. John T. Sullivan
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  2. Kate M. Fraser
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  3. Stephen B. Fleming
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  4. Anthony J. Robinson
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  5. Andrew A. Mercer
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Sullivan, J.T., Fraser, K.M., Fleming, S.B. et al. Sequence and transcriptional analysis of an orf virus gene encoding ankyrinlike repeat sequences. Virus Genes 9, 277–282 (1995). https://doi.org/10.1007/BF01702883

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  • DOI: https://doi.org/10.1007/BF01702883

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