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Monoaminergic neurotoxins: Are they selective?

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Summary

Introduction of 6-hydroxydopamine into the cerebrospinal fluid produces a selective destruction of adrenergic pathways. However, the selectivity of interstitial injections of 6-hydroxydopamine for catecholamine elements is critically dependent upon the dose and volume of injection and must be evaluated by biochemical and cytochemical indices.

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References

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Author notes

  1. F. E. Bloom

    Present address: Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C., USA

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    1. F. E. Bloom
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    Some perspectives on the symposium held at theFourth Annual Meeting of theSociety for Neuroscience, October, 1974.

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    Bloom, F.E. Monoaminergic neurotoxins: Are they selective?. J. Neural Transmission 37, 183–187 (1975). https://doi.org/10.1007/BF01670127

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    • DOI: https://doi.org/10.1007/BF01670127

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