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The role of histamine and histamine receptors in the pathogenesis and treatment of erosive gastritis

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Abstract

Experiments have demonstrated the importance of histamine and intraluminal acid in the pathogenesis of gastric stress erosions. Histamine H2 receptor antagonists were found to protect against stress ulcers and bleeding in experimental animals and in patients at risk. The seriousness of this clinical problem has been almost eliminated by the use of antacids or histamine antagonists designed to reduce intraluminal gastric acidity.

Résumé

De nombreuses études expérimentales ont démontré que l'histamine et la présence d'acide dans la lumière gastrique jouent un rôle important dans la pathogénie des érosions gastriques de stress. Les antagonistes des récepteurs H2 protègent contre l'ulcère de stress et ses hémorragies chez l'animal et chez l'homme, dans les conditions où ces lésions risquent d'apparaître. Ce problème clinique fort grave a presque disparu depuis que l'on utilise des anti-acides ét des antagonistes de l'histamine pour réduire l'acidité du suc gastrique.

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Authors and Affiliations

  1. Department of Surgery, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa, USA

    Nelson J. Gurll M.D. & Aristotle J. Damianos

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  1. Nelson J. Gurll M.D.
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  2. Aristotle J. Damianos
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Supported in part by the Medical Research Service of the Veterans Administration.

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Gurll, N.J., Damianos, A.J. The role of histamine and histamine receptors in the pathogenesis and treatment of erosive gastritis. World J. Surg. 5, 181–186 (1981). https://doi.org/10.1007/BF01658284

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  • DOI: https://doi.org/10.1007/BF01658284

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