Summary
Twenty healthy volunteers participated in a comparative study concerning the influence ofLactobacillus acidophilus supplements on the normal intestinal microflora after the administration of two antimicrobial agents, enoxacin and clindamycin, respectively.L. acidophilus NCFB 1748 was given as a fermented milk product containing 5 × 108−2 × 109 CFU/ml to ten of the volunteers immediately after the administration of the antimicrobial agents. On the seventh day of enoxacin administration enterobacteria were eliminated in nine of ten subjects. Enterococci disappeared or decreased significantly in five subjects. During theL. acidophilus supplementation, there was a significant increase in the number ofEscherichia coli in one subject, while enterococci returned to the same level as before enoxacin administration in all subjects. In the clindamycin group, the anaerobic microflora was strongly suppressed in all volunteers. Lactobacilli disappeared in two subjects and decreased in five. Administration ofL. acidophilus resulted in a significant increase in the number of lactobacilli in all subjects, while most other anaerobic bacteria returned to the same levels as before clindamycin administration one week later. In two subjects, Bacteroides increased to earlier high levels on days 14 to 16 in theLactobacillus group, while there was no similar increase in the clindamycin group. Though there was a partial restoration of the intestinal microflora due to the reestablishment of lactobacilli and enterococci,L. acidophilus administration could not accelerate the normalization of most other strongly suppressed microorganisms in the intestine.
Zusammenfassung
Bei 20 gesunden freiwilligen Probanden wurde der Einfluß vonLactobacillus acidophilus auf die physiologische Mikroflora des Darmes nach Gabe von zwei antimikrobiellen Substanzen, Enoxacin bzw. Clindamycin, im Rahmen einer Vergleichsstudie untersucht.L. acidophilus NCFB 1748 wurde in einer Konzentration von 5 ×108 − 2 × 109 KBE/ml als fermentiertes Milchprodukt unmittelbar nach Gabe der Antibiotika an zehn der Probanden verabreicht. Bei neun der zehn Probanden waren am siebten Tag nach Gabe von Enoxacin Enterobakterien eliminiert. Bei fünf Personen verschwanden Enterokokken oder waren signifikant vermindert. WennL. acidophilus zugegeben wurde, kam es bei einer Person zu einer signifikanten Zunahme derEscherichia coli-Zahlen und in allen Fällen zu einem Anstieg der Enterokokkenzahlen auf Werte wie vor der Applikation von Enoxacin. Bei allen Probanden der Clindamycin-Gruppe war die anaerobe Mikroflora erheblich vermindert. Bei zwei Personen verschwanden Laktobazillen und gingen in fünf Fällen zurück. Bei allen Testpersonen führte die Gabe vonL. acidophilus zu einem signifikanten Anstieg der Laktobazillen, die meisten anderen anaeroben Bakterien waren nach einer Woche wieder in derselben Zahl vorhanden wie vor Gabe von Clindamycin. Bei zwei Personen derLactobacillus-Gruppe stieg die Zahl der Bacteroides-Keime an den Tagen 14–16 auf Werte wie vor Antibiotikagabe an, während in der Clindamycin-Gruppe kein vergleichbarer Anstieg zu verzeichnen war. Obwohl es durch Regeneration der Laktobazillen und Enterokokken zu einer teilweisen Wiederherstellung der intestinalen Mikroflora kam, konnte durch Gabe vonL. acidophilus die Normalisierung der meisten übrigen, stark supprimierten Mikroorganismen im Darm nicht beschleunigt werden.
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Lidbeck, A., Edlund, C., Gustafsson, J.Å. et al. Impact of Lactobacillus acidophilus on the normal intestinal microflora after administration of two antimicrobial agents. Infection 16, 329–336 (1988). https://doi.org/10.1007/BF01644541
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DOI: https://doi.org/10.1007/BF01644541