Abstract
Despite the increasing incidence of cocaine abuse and its known vasoactive properties, the vascular consequences of cocaine use are incompletely defined. Cocaine-related myocardial ischemia has been described and is thought to occur secondary to vasospasm. Infrequently reported cases of cocaine-related visceral ischemia have been attributed to vasoconstriction. We report here the first described case of serial infarctions in distinct vascular beds, myocardial and mesenteric. The case report and review of the literature support the concept of a diffuse, severe, and potentially lethal vasoconstrictive effect of cocaine.
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References
Goldfrank LR, Hoffman RS (1991) The cardiovascular effects of cocaine. Ann Emerg Med 20:165–175.
Isner JM, Chokski SK (1990) Cocaine-related heart disease. In: Heart Disease: A Textbook of Cardiovascular Medicine: Update 14, Braunwald E (ed). WB Saunders: New York.
Isner JM, Chokski SK. Cocaine and vasospasm. N Engl J Med 321:1604–1607.
Lange RA, Cigarroa RG, Yancy CQ Jr, et al (1989) Cocaine-induced coronary vasoconstriction. N Engl J Med 321:1557–1562.
Freundenberger RS, Cappell MS, DA (1990) Hutt intestinal infarction after intravenous cocaine administration. Ann Intern Med 113:715–716.
Nalbandian H, Sheth N, Dietrich R, Georgiou J (1985) Intestinal ischemia caused by cocaine ingestion: Report of two cases. Surgery 97:374–376.
Sharff JA (1984) Renal infarction associated with intravenous cocaine use. Ann Emerg Med 13:1145–1147.
Novielli KD, Chambers CV (1990) Splenic infarction after cocainc use. Ann Intern Med 114:251–252.
Lee HS, LaMaute HR, Pizzi WF, Picard DL, Luks FI (0000) Acute gastroduodenal perforations associated with use of crack. Ann Surg 211:15–17.
Smith HWB III, Liberman HA, Brody SL, Battey LL, Donohue BC, Morris DC (1987) Acute myocardial infarction temporarily related to cocaine use: Clinical, angiographic and pathophysiologic observations. Ann Intern Med 107:13–18.
Egashira K, Pipers FS, Morgan JP (1991) Effects of cocaine on epicardial coronary artery reactivity in miniature swine after endothelial injury and high cholesterol feeding: in vivo and in vitro analysis. J Clin Invest 00:1307–1314.
Majoid PA, Patel B, Kim HS, Simmerman JL, Delinger RP (1990) An angiographic and histologic study of cocaine-induced chest pain. Am J Cardiol 65:812–814.
Togna G, Tempesta E, Togna AR, et al (1985) Platelet responsiveness and biosynthesis of thromboxane and prostacycline in response to in vitro cocaine treatment. Hemostasis 15:100–105.
Leissinger CA (1990) Severe thrombocytopenia associated with cocaine use. Ann Intern Med 112:708–710.
Orser B (1991) Thrombocytopenia and cocaine abuse. Anesthesiology 74:195–196.
Chokski SK, Miller G, Rongione A, Isner JM (1989) Cocaine and cardiovascular diseases: The leading edge. Cardiology 111:1–6.
Virmani R, Robinowitz M, Smialek JE, Smyth DF (1988) Cardiovascular effects of cocaine: An autopsy study of 40 patients. Am Heart J 115:1068–1076.
Wilson C, Gupta R, Gilmour DG, Imrie CS (1987) Acute superior mesenteric ischemia. Br J Surg 74:279–281.
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Schulz, J., Sumpio, B.E. & Gusberg, R.J. Cocaine-associated myocardial and mesenteric ischemia: A case report and review of the literature. International Journal of Angiology 7, 1–5 (1998). https://doi.org/10.1007/BF01616266
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DOI: https://doi.org/10.1007/BF01616266