Abstract
Bone morphogenetic protein (BMP) is a potent induction factor for new bone formation including heterotopic chondro-ossification in soft tissues. The immunohistochemical reaction for BMP was studied in 23 cases of pleomorphic adenoma of salivary gland by using a monoclonal antibody produced by hybridoma technique. Positive BMP immunoreactivity was seen in 87% of tumours. Immunohistochemical expression of BMP was observed in modified myoepithelial cells (88% cases), luminal tumour cells of tubulo-ductal structures (78% cases) and chondroid cells in hyaline tissue (22% cases). The authors concluded that the simultaneous presence of glycosaminoglycans as matrix substance and S-100 protein for calcium signalling are associated with BMP-mediated cellular activity of modified myoepithelial cells in the formation of chondroid structures in pleomorphic adenomas of the salivary glands.
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Lianjia, Y., Yan, J., Hitoshi, N. et al. An immunohistochemical study of bone morphogenetic protein in pleomorphic adenoma of the salivary gland. Vichows Archiv A Pathol Anat 422, 439–443 (1993). https://doi.org/10.1007/BF01606451
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DOI: https://doi.org/10.1007/BF01606451