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Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens

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Somatic Cell Genetics

Abstract

We have mapped two new genes to chromosome 11 which control the cell-surface expression of two distinct antigens defined by monoclonal antibodies. One of the antigens has a general tissue distribution and is associated with a molecular complex of two polypeptides of 80,000 dalton and 40,000 dalton molecular weight. The second antigen has a restricted tissue distribution and is carried on a polypeptide of 100,000 daltons. We have used a combination of genetic and biochemical techniques to demonstrate that these new markers are distinct from the antigens defined by the monoclonal antibodies F10.44.2 and W6/34 which are also encoded by genes on chromosome 11. It is concluded that human chromosome 11 carries at least four distinct genes controlling cell-surface antigen expression.

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Authors and Affiliations

  1. Laboratory of Human Molecular Genetics, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, WC2A 3PX, London

    A. Tunnacliffe, P. Goodfellow & G. Banting

  2. Laboratory of Somatic Cell Genetics, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, WC2A 3PX, London

    E. Solomon

  3. Wistar Institute for Anatomy and Biology, 36 and Spruce Sts., 94306, Philadelphia, Pennsylvania

    B. B. Knowles & P. Andrews

Authors
  1. A. Tunnacliffe
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  2. P. Goodfellow
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  3. G. Banting
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  4. E. Solomon
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  5. B. B. Knowles
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  6. P. Andrews
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Tunnacliffe, A., Goodfellow, P., Banting, G. et al. Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens. Somat Cell Mol Genet 9, 629–642 (1983). https://doi.org/10.1007/BF01574263

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  • DOI: https://doi.org/10.1007/BF01574263

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