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The major histocompatibility complex of the chicken

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Summary

B identifies a system of two or more loci which have major effects on hostversus-graft and graft-versus-host reactions. LikeH-2 andHL-A, B encodes lymphocyte antigens which react with alloantibodies and allogenic lymphocytes. Like the mammalian MHCs,B has many alleleic variants. LikeH-2 alleles, some of these are associated with specific differences in immune competence and susceptibility to viral oncogenesis. UnlikeH-2, there is no evidence thatB histocompatibility andB serology represent separable genetic systems. In addition,B is associated with functional differences unknown in mammals. These include a general difference in immune competence and differences in the frequency of herpesvirus lymphoma and in reproductive and general fitness. We conclude that the different kinds of information available forB and the mammalian MHCs reflect differences in circumstance, sampling, and technique, and should be regarded as less fundamental than the immunogenetic similarities. We suggest thatB is the phylogenetic homologue ofH-2 andHL-A.

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Authors and Affiliations

  1. Department of Zoology, University of Alberta, T6G 2EI, Edmonton, Alberta, Canada

    Feldzgeritta Pazderka & Royal F. Ruth

  2. Department of Immunology, University of Alberta, T6G 2EI, Edmonton, Alberta, Canada

    Bryan M. Longenecker

  3. Department of Animal Sciences, Colorado State University, 80521, Fort Collins, Colorado

    George R. J. Law

Authors
  1. Feldzgeritta Pazderka
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  2. Bryan M. Longenecker
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  3. George R. J. Law
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  4. Royal F. Ruth
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Pazderka, F., Longenecker, B.M., Law, G.R.J. et al. The major histocompatibility complex of the chicken. Immunogenetics 2, 101–130 (1975). https://doi.org/10.1007/BF01572280

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