Abstract
Partially inbred lines of Syrian hamsters, the descendants of animals caught wild in Syria within the past decade, have been studied to determine their immunogenetic relationships to the long established domestic inbred strains. These new sources of hamster genes display strong alloimmune reactions when confronted with tissues from the domestic inbred strains and vice versa: acute skin graft rejection, strong mixed lymphocyte reactions, and intense graft-versus-host reactions. While these forms of reactivity have also characterized the disparities among the domestic inbred strains, no evidence of alloantibodies specific for putative transplantation antigens has ever been found in hamsters. We report, for the first time, that immunization of recently wild hamsters with tissues from domestic inbred strain donors elicits high titer cytotoxic antibodies directed at alloantigens. Similarly, animals of the domestic inbred strains produce comparably strong alloantibody responses when immunized with tissues from the recently wild hamsters. Availability of these alloantisera will make the possibility of defining the major histocompatibility complex equivalent in this species much more likely.
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Actams, R. A., Patti, D. I., and Lutz, B. R.: Long term persistence of skin homografts in untreated hamsters.Transplant. Bull. 3: 41–42, 1956
Billingham, R. E. and Hildemann, W. H.: Studies on the immunological responses of hamsters to skin homografts.Proc. R. Soc. Lond. (Biol.) 148: 216, 1958
Billingham, R. E., Sawchuck, G. H., and Silvers, W. K.: Studies on the histocompatibility genes of the Syrian hamster.Proc. Natl. Acad. Sri. 46: 1079, 1960
Billingham, R. E. and Silvers, E. K.:Transplantation of Tissues and Cells, Wistar Institute Press, Philadelphia, Pennsylvania, 1961
Duncan, W. R. and Streilein, J. W.: Analysis of the major histocompatibility complex in Syrian hamsters. I. Skin graft-rejection, graft-versus-host reactions, mixed lymphocyte reactions and immune response genes in inbred strains.Transplantation 25: 12–16, 1978a
Duncan, W. R. and Streilein, J. W.: Analysis of the major histocompatibility complex in Syrian hamsters. II. Linkage studies.Transplantation 25: 17–22, 1978 b
Gye, W. E. and Foulds, L. A.: Note on the production of Sarcomata in hamsters by 3: 4-Benzpyrene.Am. J. Cancer 35: 108, 1939
Klein, J., Hauptfeld, V., and Hauptfeld, M.: Evidence for a fifth (G) region in theH-2 complex of the Mouse,lmmunogenetics 2: 141–150, 1975
Klein, J.:Biology of the Mouse Histocompatibility-2 Complex, Springer-Verlag, New York, 1975
Lause, D. and Streilein, J. W.: An in vivo and in vitro analysis of the alloantigen response in Syrian hamsters.Transplantation 24: 211–217, 1977
Murphy, M. R.: Natural history of the Syrian golden hamster - a reconnaissance expedition.Am. Zool. 11: 632, 1971
Phillips, J. T., Streilein, J. W., and Duncan, W. R.: The biochemical characterization of Syrian hamster cell-surface alloantigens. I. Analysis of allogeneic differences between recently wild and highly inbred hamsters.lmmunogenetics 7: 445–455, 1978
Shreffler, D. C. and David, C. S.: The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.Adv. Immunol. 20: 125–195, 1975
Silvers, W. K., Gasser, D. L., and Murphy, M. R.: Number of histocompatibility loci in Syrian hamsters.J. Immunol. 115: 1309–1311, 1975
Singh, S. H. and Tevethia, S. S.: Demonstration of mixed lymphocyte interactions in hamsters.Proc. Soc. Exp. Biol. Med. 142: 443, 1973
Streilein, J. W. and Billingham, R. E.: An analysis of graft-versus-host disease in Syrian hamsters. I. Epidermolytic syndrome: description and studies on its procurement.J. Exp. Med. 132: 168, 1970
Wilson, D. B. and Elkins, W. L.:In W. O. Rieke (ed.):Proceedings of the 3rd Annual Leukocyte Culture Conference, p. 391, Appleton-Century-Crofts, New York, 1967
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Streilein, J.W., Duncan, W.R. Alloimmune reactions among recently wild syrian hamsters and classical inbred strains include alloantibody production. Immunogenetics 9, 563–573 (1979). https://doi.org/10.1007/BF01570450
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DOI: https://doi.org/10.1007/BF01570450