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Ultrastructure, in vitro and in vivo, of staphylococci exposed to antibiotics

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Abstract

The ultrastructure of staphylococci from the peritoneal fluid of mice treated with oxacillin and from sputum of a patient treated with ampicillin was comparable to the structure of staphylococci grown on filter membranes exposed to oxacillin, but was different from the same organisms grown in broth with oxacillin. The selection of a solid phase support growth medium, such as a filter membrane for in vitro studies of drug induced morphology, appears necessary if such studies are to reflect bacterial ultrastructure in vivo.

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Authors and Affiliations

  1. Division of Microbiology, Department of Pathology, The Bronx Lebanon Hospital Center and Albert Einstein College of Medicine, 1276 Fulton Avenue, 10456, Bronx, New York, USA

    Victor Lorian, Barbara Atkinson, Alexandra Waluschka & Yehum Kim

Authors
  1. Victor Lorian
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  2. Barbara Atkinson
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  3. Alexandra Waluschka
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  4. Yehum Kim
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Lorian, V., Atkinson, B., Waluschka, A. et al. Ultrastructure, in vitro and in vivo, of staphylococci exposed to antibiotics. Current Microbiology 7, 301–304 (1982). https://doi.org/10.1007/BF01566867

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