Summary
Using Newcastle disease virus (NDV), the precision of a virus assay system in which 10-fold dilution steps were employed was compared with that of a system using narrower dilution steps and an increased number of test units for each dilution level. A comparison of the accuracy obtained by using a complex single titration was made with that obtained by combining the results of three smaller titrations. It is suggested that the latter is a more valuable method as it will reduce any technical errors which would pass unnoticed in a single titration.
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References
Finney, D. J.: Statistical method in biological assay. 2nd ed. London: Griffin, 1964.
Reed, L. J., andH. Muench: Amer. J. Hyg.27, 493 (1938).
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Allan, W.H., Hebert, C.N. The precision of virus end-point determinations. Archiv f Virusforschung 25, 330–336 (1968). https://doi.org/10.1007/BF01556561
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DOI: https://doi.org/10.1007/BF01556561