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A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12

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Somatic Cell Genetics

Abstract

A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.

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Authors and Affiliations

  1. The Wistar Institute, 36 Street at Spruce, 19104, Philadelphia, Pennsylvania

    Peter W. Andrews & Barbara B. Knowles

  2. Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX, London, UK

    Peter N. Goodfellow

Authors
  1. Peter W. Andrews
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  2. Barbara B. Knowles
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  3. Peter N. Goodfellow
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Andrews, P.W., Knowles, B.B. & Goodfellow, P.N. A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12. Somat Cell Mol Genet 7, 435–443 (1981). https://doi.org/10.1007/BF01542988

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  • DOI: https://doi.org/10.1007/BF01542988

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