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Genetics of somatic cell surface antigens. III. Further analysis of the AL marker

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Somatic Cell Genetics

Abstract

The A L antigen present on the surface of various human somatic cells, and on those hybrids of human and Chinese hamster ovary cells which have retained human chromosome number 11, has been resolved into at least two separate antigenic activities, a1 and a2. Specific antisera active against each antigen separately have been prepared. By treatment of the original AL + hybrid with mutagenic agents and selection in particular antisera, stable clones are preparable whose phenotypic behavior corresponds to the antigenic compositions a1 + a2 −, a1 − a2 +, and a1 − a2 −. The adsorption behavior of these variants for specific antisera is consistent with their phenotypic assignments.

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Authors and Affiliations

  1. University of Colorado Medical Center, Denver, Colorado

    Carol Jones, Paul Wuthier & Theodore T. Puck (Research Professor)

  2. American Cancer Society, USA

    Theodore T. Puck (Research Professor)

Authors
  1. Carol Jones
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  2. Paul Wuthier
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  3. Theodore T. Puck
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Jones, C., Wuthier, P. & Puck, T.T. Genetics of somatic cell surface antigens. III. Further analysis of the AL marker. Somat Cell Mol Genet 1, 235–246 (1975). https://doi.org/10.1007/BF01538448

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  • DOI: https://doi.org/10.1007/BF01538448

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