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Effects of the beta2-adrenoceptor agonists fenoterol and salbutamol on force of contraction in isolated human ventricular myocardium

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Summary

The effects of fenoterol and salbutamol on isometric force of contraction were studied in isolated, electrically driven human papillary muscle preparations. Fenoterol increased force of contraction at concentrations of 1 µmol l−1 and higher. The maximally effective concentration of fenoterol (100 µmol l−1) increased force of contraction by about 130%. The positive inotropic effect of fenoterol was not influenced by 0.1 µmol l−1 prazosin. The beta1-selective antagonist atenolol (2 µmol l−1) and the beta2-selective antagonist ICI 118551 (1 µmol l−1) shifted the concentration-response curve of fenoterol to the right, indicating that beta1- and beta2-adrenoceptors may contribute to the positive inotropic effect of fenoterol. In contrast to fenoterol, salbutamol increased force of contraction only by about 11% at 100 µmol l−1. The results indicate that: (1) fenoterol exerts a direct positive inotropic effect in the human heart which may support the beneficial effects of the reduction of systemic vascular resistance in patients with congestive heart failure; (2) this positive inotropic effect of fenoterol is mediated by beta1- and beta2-adrenoceptors; (3) the clinically observed improvement of cardiac performance in the case of salbutamol is presumably not due to any direct positive inotropic effect.

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Abbreviations

mN:

millinewton

EC50 :

half maximal effective concentration

SEM:

standard error of the mean

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Authors and Affiliations

  1. Abteilung Allgemeine Pharmakologie, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Germany

    A. Mügge, D. Posselt, U. Reimer, W. Schmitz & H. Scholz

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  1. A. Mügge
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  2. D. Posselt
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  3. U. Reimer
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  4. W. Schmitz
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  5. H. Scholz
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Mügge, A., Posselt, D., Reimer, U. et al. Effects of the beta2-adrenoceptor agonists fenoterol and salbutamol on force of contraction in isolated human ventricular myocardium. Klin Wochenschr 63, 26–31 (1985). https://doi.org/10.1007/BF01537483

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  • DOI: https://doi.org/10.1007/BF01537483

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