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Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats

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Abstract

Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and l-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow. Similar effects were not observed with administration of MAO A inhibitors. These observations suggest that activation of central dopamine and norepinephrine receptors, particularly in NACB, are involved in the control of gastric mucosal function.

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, The Milton S. Hershey Medical Center, The Pennsylvania State University, 17033, Hershey, Pennsylvania

    Lianping Xing MD, John Washington, John Seaton BS & Gordon Kauffman Jr MD

Authors
  1. Lianping Xing MD
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  2. John Washington
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  3. John Seaton BS
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  4. Gordon Kauffman Jr MD
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Supported by PHS grant DK 38198 (G.K.).

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Xing, L., Washington, J., Seaton, J. et al. Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats. Digest Dis Sci 35, 61–65 (1990). https://doi.org/10.1007/BF01537224

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  • DOI: https://doi.org/10.1007/BF01537224

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