Summary
Primary malignant lymphomas of the liver are extremely rare. Thus far, 28 cases (1–13) of this entity have been described, but after careful clinical and histological staging, no other sites of extrahepatic involvement were demonstrated in 17 of these cases (2, 3, 5–13). We recently had the opportunity to investigate and manage a case of true primary malignant peripheral T-cell lymphoma of the liver in a 22-year-old man. To our knowledge this is the first reported case of a primary T-cell lymphoma of the liver. The patient was successfully treated with a right trisegmentectomy and no tumor recurrence has appeared after five years.
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Alami SY, Bowman RO, Reese MH, Race GJ: Extranodal lymphosarcoma of the left liver lobe with paraproteinemia. Arch Intern Med 123:64–68, 1968
Torres A: Primary lymphocytic follicular lymphoma of liver. Cancer 23:1185–1189, 1969
Torres A, Bozzolos GD: Primary reticulum cell sarcoma of liver. Cancer 27:1489–1492, 1971
Freeman C, Berg JW, Cutler SJ: Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260, 1972
Francillon J, Vignal J, Lesbros F, Guyon JM, Tissot E: Lymphosarcome à localisation hepatique pure. Chirurgie 100:566–570, 1974
Chambers TJ, O'Donoghue P, Stansfeld AG: A case of primary lymphoma of the liver. J Clin Pathol 29:967–970, 1976
Talamo TS, Dekker A, Gurecki J, Singh G: Primary hepatic malignant lymphoma. Cancer 46:336–339, 1980
Strayer DS, Reppun TS, Levin M, Deschryver-Kecskemeti K: Primary lymphoma of the liver. Gastroenterology 78:1571–1576, 1980
Leahy MF, Ibrahim EM, Worth AJ: Primary hepatic lymphoma: Two case reports and a review of the literature. Med Pediatr Oncol 10:575–581, 1982
Daniel SJ, Attiyeh FF, Dire JJ, Pyun HI, Carroll DS, Attia A: Primary lymphoma of the liver treated with extended left hepatic lobectomy. Cancer 55:206–209, 1985
Osborne BM, Butler JJ, Guarda LA: Primary lymphoma of the liver. Ten cases and a review of the literature. Cancer 56:2902–2910, 1985
Colli A, Elli GM, Cocciolo M, Morandi P, Bratina G, Scaltrini G: Non-Hodgkin lymphoma localized in the liver: Report of a case without involvement of the other tested districts. Hematologica 71:229–231, 1986
Czerniak A, Soreide O, Halnan K, Krausz T, Edwards H, Blumgart LH: Primary non-Hodgkin lymphoma of the liver. Eur J Surg Oncol 13:251–255, 1987
Loehr WJ, Mujahed Z, Zahan FD, Gray GF, Thorbjarnarson B: Primary lymphoma of the gastrointestinal tract: A review of 100 cases. Ann Surg 170:232–238, 1969
Contreary K, Nance FC, Becker WF: Primary lymphoma of the gastrointestinal tract. Ann Surg 191:593–598, 1980
Crowley KS, Don G, Gibson GE, Juttner CA, Miliauskas JR: Primary gastrointestinal tract lymphoma: A clinical study of 28 cases. Aust NZ J Med 12:135–142, 1982
Gray GM, Rosenberg SA, Cooper AD, Gregory PB, Stein DT, Herzenberg H: Lymphomas involving the gastrointestinal tract. Gastroenterology 82:143–152, 1982
Novak S, Caraveo J, Trowbridge AA, Peterson RF, White RR: Primary lymphoma of the gastrointestinal tract. South Med J 72:1154–1158, 1979
ReMine SG: Abdominal lymphoma. Surg Clin North Am 65:301–313, 1985
Risdall R, Hoppe RT, Warnke R: Non-Hodgkin lymphoma. A study of the evolution of the disease based upon 92 autopsied cases. Cancer 44:529–542, 1979
Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, van Unnik JAM, Wright DH: Updated Kiel classifications for lymphomas. Lancet 1:292–293, 1988
National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a Working Formulation for clinical usage. Cancer 49:2112–2135, 1982
Anthony PP, Telesinghe PU: Inflammatory pseudotumor of the liver. J Clin Pathol 39:761–768, 1986
Norton AJ, Ramsay AD, Smith SH, Beverly PCL, Isaacson PG: Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol 39:399–405, 1966
Davey FR, Gatter KC, Ralfkiaer E, Pulford KAF, Krissansen GW, Mason DY: Immunophenotyping of non-Hodgkin lymphomas using a panel of antibodies on paraffinembedded tissues. Am J Pathol 129:54–63, 1987
Hall PA, D'Ardenne AJ, Butler MG, Habeshaw JR, Stansfeld AG: New marker of B lymphocytes, MB2: Comparison with other lymphocyte subset markers active in conventionally processed tissue sections. J Clin Pathol 40:151–156, 1987
Linder J, Ye Y, Harrington DS, Armitage JO, Weisenburger DD: Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue. Am J Pathol 127:1–8, 1987
Smith SH, Brown MH, Rowe D, Callard RE, Beverely PC: Functional subsets of human helper-inducer cells defined by a new monoclonal antibody (UCHL1). Immunology 58:63–69, 1986
Bonadonna G, Valagussa P: Should Lymphomas of the gastrointestinal tract be treated differently from other disease presentation? Eur J Cancer Clin Oncol 11:1295–1299, 1986
Hande KR, Fisher RI, De Vita VT, Chabner BA, Young RC: Diffuse histiocytic lymphoma involving the gastrointestinal tract. Cancer 41:1984–1988, 1978
Nims TA: Resection of the liver for metastatic cancer. Surg Gynecol Obstet 158:46–48, 1984
Taylor B, Langer B, Falk RE, Ambus U: Role of resection in the management of metastases to the liver. Can J Surg 26:215–217, 1983
Fortner JG, Silva JS, Golbey RB: Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. I. Treatment by hepatic resection. Ann Surg 199:576–583, 1984
Kortz WJ, Meyers WC, Hanks JB: Hepatic resection for metastatic cancer. Ann Surg 199:182–186, 1984
Wilson SM, Adson MA: Surgical treatment of hepatic metastases from colorectal cancers. Arch Surg 111:330–334, 1976
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Andreola, S., Audisio, R.A., Mazzaferro, V. et al. Primary lymphoma of the liver showing immunohistochemical evidence of T-cell origin. Digest Dis Sci 33, 1632–1636 (1988). https://doi.org/10.1007/BF01535958
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DOI: https://doi.org/10.1007/BF01535958