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T-Cell Non-Hodgkin’s Lymphomas: Variant Forms

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

There are several variant forms of T-cell non-Hodgkin’s lymphomas that can involve the hepatobiliary tract. A distinct and highly aggressive variety of T-cell NHL is the lymphoepithelioid cell variant of peripheral T-cell lymphoma, also termed Lennert’s lymphoma (LECL). LECL is characterized by a proliferation of CD4-positive T cells associated with high content of epithelioid macrophages/histiocytes. LECL exhibits a high incidence of generalized lymphadenopathy but rare extranodal disease. Liver involvement may occur, with variable degrees of hepatomegaly. A variant of peripheral T-cell NHL with a polymorphous T-cell lymphoproliferation and association with EBV infection and systemic disease is angioimmunoblastic T-cell lymphoma. This neoplasm accounts for 15–20 % of T-cell NHL. Hepatosplenomegaly is a frequent feature, and the liver shows infiltration by polymorphous lymphoid cells of the T-cell class associated with angiogenesis.

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    Arthur Zimmermann

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Zimmermann, A. (2017). T-Cell Non-Hodgkin’s Lymphomas: Variant Forms. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_96

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