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Modulation of carrageenan-induced hind paw edema by substance P

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Abstract

Substance P has been implicated as a mediator of inflammation. The involvement of this neuropeptide in carrageenan-induced hind paw edema in the rat was assessed. Subcutaneous injection of carrageenan into the rat paw caused a significant increase in substance P levels, which preceded the onset of inflammation. While injection of substance P alone caused mild edema, coadministration of submaximal doses of carrageenan and substance P resulted in a synergistic exacerbation in the degree of inflammation. This synergistic response was not detected when the nonamidated precursor of substance P was coinjected with carrageenan. The effects of substance P depletion on inflammation were also evaluated. In animals pretreated with capsaicin followed by injection with carrageenan, no significant increase in either the levels of substance P or the extent of edema was observed when compared to capsaicin-treated controls. These results indicate that substance P may play an important role in the early stages of carrageenan-induced paw edema and that a reduction in the biosynthesis of substance P may lessen the severity of this inflammatory response.

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Author notes

  1. Susan J. Lovato

    Present address: Sandoz Pharmaceuticals, 07936, East Hanover, New Jersey

  2. Mark D. Erion

    Present address: Gensia, Inc., 92121, San Diego, California

Authors and Affiliations

  1. Unigene Laboratories, 07006, Fairfield, New Jersey

    James P. Gilligan & Susan J. Lovato

  2. Research Department, Pharmaceuticals Division, CIBA-GEIGY Corp., 07901, Summit, New Jersey

    Mark D. Erion & Arco Y. Jeng

Authors
  1. James P. Gilligan
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  2. Susan J. Lovato
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  3. Mark D. Erion
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  4. Arco Y. Jeng
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Gilligan, J.P., Lovato, S.J., Erion, M.D. et al. Modulation of carrageenan-induced hind paw edema by substance P. Inflammation 18, 285–292 (1994). https://doi.org/10.1007/BF01534269

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