Skip to main content
SpringerLink
Log in

An enzymological approach to mitochondrial energy transduction

  • Published:
Journal of bioenergetics Aims and scope Submit manuscript

Abstract

An approach to the problem of mitochondrial energy transduction is outlined. The approach is based on the fundamental assumption that there is an intimate relation between the mechanisms of enzyme catalysis and energy transduction. The implications of this assumption for the coupling of two chemical reactions and the coupling of a chemical reaction to an ion flux are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. E. Green,Proc. Nat. Acad. Sci. U.S.,67, (1970) 544.

    Google Scholar 

  2. D. E. Green and J. H. Young,Amer. Sci.,59 (1971) 92.

    PubMed  Google Scholar 

  3. R. Lumry, in:A Treatise on Electron and Coupled Energy Transfer in Biological Systems, T. King and M. Klingenberg (eds.), Dekker, New York, 1969.

    Google Scholar 

  4. P. D. Boyer, in:Biological Oxidations, T. P. Singer (ed.), Interscience, New York, 1968, p. 193.

    Google Scholar 

  5. R. Lumry and R. Biltonen, in:Structure and Stability of Biological Macromolecules, S. N. Timasheff, G. D. Fasman, (eds.), Dekker, New York, 1969, p. 65.

    Google Scholar 

  6. W. Jencks, in:Current Aspects of Biochemical Energetics: Fritz Lipman Dedicatory Volume, N. Kaplan and E. Kennedy (eds.), Academic Press, New York, 1966, p. 272.

    Google Scholar 

  7. D. Koshland, Jr.,Proc. Nat. Acad. Sci. U.S.,44 (1958) 98;Cold Spring Harbor Symp. Quat. Biol.,28 (1963) 473.

    Google Scholar 

  8. I. Prigogine,Introduction to Thermodynamics of Irreversible Processes, 3rd Ed., Interscience, New York, 1967, p. 25.

    Google Scholar 

  9. H. Rottenberg, S. R. Caplan and A. Essig, in:Membranes and Ion Transport, Vol. 1, E. Bittar (ed.), Interscience, New York, 1970, p. 165.

    Google Scholar 

  10. M. Klingenberg and P. Schollmeyer,Proc. 5th Intern. Congr. Biochem., Moscow 1961, Vol. 5, Pergamon, London, 1963, p. 46.

    Google Scholar 

  11. S. Muraoka and E. C. Slater,Biochim. Biophys. Acta,180 (1969) 221.

    PubMed  Google Scholar 

  12. G. F. Azzone and S. Massari,Eur. J. Biochem.,19 (1971) 97.

    PubMed  Google Scholar 

  13. E. Rossi and G. F. Azzone,Eur. J. Biochem.,12 (1970) 319.

    PubMed  Google Scholar 

  14. R. S. Cockrell, E. J. Harris and R. Pressman,Nature,215 (1967) 1487.

    PubMed  Google Scholar 

  15. R. A. Reid, J. Moyle and P. Mitchell,Nature,212 (1966) 257.

    PubMed  Google Scholar 

  16. L. Danielson and L. Ernster, in:Energy-Linked Functions of Mitochondria, B. Chance (ed.), Academic Press, New York, 1963, p. 157.

    Google Scholar 

  17. R. J. van de Stadt, F. J. R. M. Nienwenhuis and K. van Dam,Biochim. Biophys. Acta,234 (1971) 173.

    PubMed  Google Scholar 

  18. L. L. Grinius, A. A. Jasaitis, Y. P. Kadziauskas, E. A. Liberman, V. P. Skulachev, V. P. Topali, L. M. Tsofina and M. A. Vladimirova,Biochim. Biophys. Acta,216 (1970) 1.

    PubMed  Google Scholar 

  19. L. Ernster and C. P. Lee,Ann. Rev. Biochem.,33 (1964) 729.

    PubMed  Google Scholar 

  20. M. Klingenberg,Essays Biochem.,6 (1970) 119.

    PubMed  Google Scholar 

  21. J. H. Young (manuscript in preparation).

  22. P. D. Boyer, in:Current Topics in Bioenergetics, Vol. II, D. R. Sanadi (ed.), Academic Press, New York, 1967, p. 99.

    Google Scholar 

  23. P. Mitchell,Biol. Rev. Cambridge Phil. Soc.,41 (1966) 445.

    Google Scholar 

  24. J. H. Young, G. A. Blondin and D. E. Green, in:Physical Principles of Neuronal and Organismic Behavior, Gordon and Breach, New York, in press.

  25. J. H. Young, G. A. Blondin and D. E. Green,Proc. Nat. Acad. Sci. USA,68 (1971) 1364.

    PubMed  Google Scholar 

  26. E. A. Liberman and V. P. Skulachev,Biochim. Biophys. Acta,216 (1970) 30.

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. John H. Young

    Present address: School of Pharmacy, University of Wisconsin, Madison, Wisconsin

Authors and Affiliations

  1. Institute for Enzyme Research, The University of Wisconsin, 53706, Madison, Wisconsin

    John H. Young

Authors
  1. John H. Young
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Young, J.H. An enzymological approach to mitochondrial energy transduction. J Bioenerg Biomembr 3, 137–146 (1972). https://doi.org/10.1007/BF01516004

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01516004

Keywords

Search

Navigation