Summary
The effects of tolbutamide, glibenclamide, arginine and arginine in combination with glibenclamide upon insulin, glucagon and glucose serum levels have been studied in healthy young men.
Sulphonylurea-induced hypoglycemia is followed by a reactive hyperglucagonemia. Arginine-induced hyperglucagonemia is not suppressed by sulphonylureas. While there exists no difference between tolbutamide and glibenclamide-stimulated glucagon secretion, there is one with regard to insulin secretion.
Zusammenfassung
An stoffwechselgesunden männlichen Probanden wurde das Verhalten von Insulin, Glukagon und Plasmaglucose nach Gabe von Tolbutamid, Glibenclamid sowie von Arginin mit und ohne Glibenclamidzusatz kontrolliert.
Die Untersuchungen ergaben, daß die sulfonylharnstoffinduzierte Hypoglykämie eine reaktive Hyperglukagonämie nach sich zieht. Die Arginininduzierte Hyperglukagonämie wird durch Sulfonylharnstoffe nicht supprimiert. Unterschiede zwischen Tolbutamid und Glibenclamid bestehen hinsichtlich des Insulin, — nicht jedoch des Glukagoninkretionsmusters.
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Baumeister, G., Wagner, H. & Stahl, M. Klinisch experimentelle Untersuchungen zur Beeinflussung der pankreatischen Glukagoninkretion durch Tolbutamid und Glibenclamid. Klin Wochenschr 53, 571–574 (1975). https://doi.org/10.1007/BF01468901
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DOI: https://doi.org/10.1007/BF01468901