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Response of immunoreactive parathyroid hormone to intravenous phosphate infusion in primary hyperparathyroidism

Stimulierung des immunreaktiven Parathormons im Serum mit Phosphatinfusion bei primärem Hyperparathyreoidismus

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Summary

Serum immunoreactive parathyroid hormone (iPTH) was estimated before and after phosphate infusions (3 hr) in 8 patients with hyperparathyroidism later proven surgically. An increase in iPTH was invariably observed. The increase expressed as the percentage of the basal iPTH was related to the decrease of the serum calcium concentration, suggesting that induced hypocalcaemia increased PTH secretion in primary hyperparathyroidism.

Zusammenfassung

Die Konzentration des immunoreaktiven Parathormons im Serum (iPTH) vor und nach Phosphatinfusion (3 Std) wurde bei 8 Patienten mit später chirurgisch verifiziertem primärem Hyperparathyreoidismus gemessen. Bei allen Patienten kam es zu einem Anstieg des iPTH. Es bestand eine enge Korrelation zwischen dem prozentualen Anstieg des iPTH und dem Abfall der Serumcalciumkonzentration. Diese Beziehung weist darauf hin, daß eine Steigerung der Parathormonsekretion durch eine Hypocalcämie beim primären Hyperparathyreoidismus hervorgerufen wird und die Sekretion deshalb nicht autonom erfolgt.

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References

  1. Arnaud, C. D., Sizemore, G. W., Oldham, S. B., Fischer, J. A., Tsao, H. S., Littledike, E. T.: Human parathyroid hormone: glandular and secreted molecular species. Amer. J. Med.50, 630 (1971)

    PubMed  Google Scholar 

  2. Arnaud, C. D., Tsao, H. S., Littledike, T.: Radioimmunoassay of human parathyroid hormone in serum. J. clin. Invest.50, 21 (1971)

    PubMed  Google Scholar 

  3. Berson, S. A., Yalow, R. S.: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science154, 907 (1966)

    PubMed  Google Scholar 

  4. Binswanger, U., Fischer, J. A.: Effect of parathyroid hormone and calcium on tubular reabsorption of phosphate in primary hyperparathyroidism (abstract). Clin. Res.21, 677 (1973)

    Google Scholar 

  5. Chen, I. W., Park, H. M., King, L. R., Goldsmith, R. E.: Plasma immunoreactive parathyroid hormone response to ethylene diamine tetra acetic acid (abstract). Clin. Res.20, 622 (1972)

    Google Scholar 

  6. Diem, K., Lentner, C.: Wissenschaftliche Tabellen, 7. Aufl. Basel: J. R. Geigy, S. A. 1968

    Google Scholar 

  7. Fiske, C. H., SubbaRow, J.: The colorimetric determination of phosphorus. J. biol. Chem.66, 375 (1925)

    Google Scholar 

  8. Moore, E. W.: Ionized calcium in normal serum, ultrafiltrates, and whole blood determined by ion-exchange electrodes. J. clin. Invest.49, 318

  9. Murray, T. M., Peacock, M., Powell, D., Monchick, J. M., Potts, J. T., Jr.: Non-autonomy of hormone secretion in primary hyperparathyroidism. Clinical Endocrinology1, 235 (1972)

    PubMed  Google Scholar 

  10. Potts, J. T., Jr., Deftos, L. J.: Parathyroid hormone, thyrocalcitonin, vitamin D, bone and bone mineral metabolism. In: Ducan's diseases of metabolism. P. K. Bondy, (ed.), 6th ed., p. 1011. Philadelphia: W. B. Saunders Co. 1969

    Google Scholar 

  11. Potts, J. T., Jr., Murray, T. M., Peacock, M., Niall, H. D., Tregear, G. W., Keutmann, H. T., Powell, D., Deftos, L. J.: Parathyroid hormone: sequence, synthesis, immunoassay studies. Amer. J. Med.50, 639 (1971)

    PubMed  Google Scholar 

  12. Purnell, D. C., Smith, L. H., Scholz, D. A., Elveback, L. R., Arnaud, C. D.: Primary hyperparathyroidism: a prospective clinical study. Amer. J. Med.50, 670 (1971)

    PubMed  Google Scholar 

  13. Reiss, E., Canterbury, J. M.: A radioimmunoassay for parathyroid hormone in man. Proc. Soc. exp. Biol. (N.Y.)128, 501 (1968)

    Google Scholar 

  14. Studer, O., Knob, M., Binswanger, U.: Kalziumionenkonzentration im Serum. Schweiz. med. Wschr.102, 305 (1972)

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department für Innere Medizin der Universität und Forschungslabor für Calciumstoffwechsel der Orthopädischen Universitätsklinik Balgrist und des Departementes für Innere Medizin Zürich, Schweiz

    Ulrich Binswanger & Jan A. Fischer

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  1. Ulrich Binswanger
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  2. Jan A. Fischer
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Supported in part by grants from the Emil-Barrell-Stiftung of Hoffmann-La Roche Co., by the Hartmann Müller-Stiftung, and by the EMDO-Stiftung, and by the “Schweizerische Verein Balgrist”.

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Binswanger, U., Fischer, J.A. Response of immunoreactive parathyroid hormone to intravenous phosphate infusion in primary hyperparathyroidism. Klin Wochenschr 52, 30–32 (1974). https://doi.org/10.1007/BF01468519

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  • DOI: https://doi.org/10.1007/BF01468519

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