Summary
Immunofluorescence is a useful tool to acquire more insight into the pathogenesis of the glomerulonephritis. It is even of more importance that one can observe distinct glomerular patterns of immunofluorescence in correlation to the different manifestations of glomerulonephritis. Immunofluorescence histology is a helpful supplement for the routine histology in order to better classifiy glomerular diseases. In some cases the diagnostic potency of immunofluorescence is superior to the conventional histology.
Zusammenfassung
Neben dem Einblick in die pathogenetischen Zusammenhänge der Glomerulonephritis gelingt es durch die Immunfluorescenz-Histologie, charakteristische Erscheinungsbilder glomerulärer Immunreaktionen abzugrenzen:Linearer Typ; akut-proliferativer Typ; Matrixvermehrung und mesangialer Typ; membranoproliferativer Typ; perimembranöser Typ; herdförmige Sklerose. Mit diesen Beobachtungen werden pathologisch-histologische Maßstäbe bestätigt und die Klassifizierung der Glomerulonephritiden erleichtert. In einigen Fällen kommt der Immunhistologie ausschlaggebende Bedeutung zu.
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Literatur
Berger, J.: IgA glomerular deposits in renal disease. Transpl. Proc.1, 939 (1969).
Boesken, W. H., Hammer, D. K.: Purification and chemical characterization of a basement membrane glycoprotein present in the urine of nephritic rabbits. Hoppe-Seylers Z. physiol. Chem.353, 1429 (1972).
Cochrane, C. G.: Mechanisms involved in the deposition of immune complexes in tissues. J. exp. Med.134, pt. 2, 75 s. (1971).
Combes, B., Slastny, P., Shorey, J., Eigenbrodt, E. H., Barrera, A., Hull, A. R., Carter, N. W.: Glomerulonephritis with deposition of Australia-antigen-antibody complexes in glomerular basement membrane. Lancet1971 II, 234.
Coons, A. H., Creech, H. J., Jones, R. N.: Immunological properties of an antibody containing a fluorescent group. Proc. Soc. exp. Biol. (N.Y.)47, 200 (1941)
Coons, A. H., Kaplan, M. H.: Localization of antigen in tissue cells. II. Improvements in a method for the dedection of antigen by means of fluorescent antibody. J. exp. Med.91, 1 (1958).
Götze, O., Müller-Eberhard, H. J.: The C3-activator system: An alternate pathway of complement activation. J. exp. Med.134, pt. 2, 90 s. (1971).
Kimmelstiel, P., Kim, O. J., Beres, J.: Studies on renal biopsy specimens, with the aid of the electron microscope II. Glomerulonephritis and glomerulonephrosis. Amer. J. clin. Path.38, 280 (1962).
Koffler, D., Schur, P., Kunkel, H.: Immunological studies concerning the nephritis of systemic lupus erythematosus. J. exp. Med.126, 607 (1967).
Koffler, D., Sandson, J., Carr, R., Kunkel, H. G.: Immunologic studies concerning the pulmonary lesions in Good-pasture's syndrome. Amer. J. Path.54, 293 (1969).
Krishnan, C., Kaplan, M. H.: Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of γ-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J. clin Invest.46, 569 (1967).
Markowitz, A. S., Lange, C. F.: Streptococcal related glomerulonephritis. I. Isolation, immunochemistry and comparative chemistry of suluble fractions from type 12 nephritogenic streptococci and human glomeruli. J. Immunol.92, 565 (1964).
Markowitz, A. S., Horn, D., Aseron, C., Novak, R., Battifora, H. A.: Streptococcal related glomerulonephritis. III. Glomerulonephritis in Rhesus monkeys immunologically induced both actively and passively with a soluble fraction from nephritogenic streptococcal protoplasmic membranes. J. Immunol.107, 504 (1971).
McCluskey, R. T.: The value of immuno-fluorescence in the study of human renal disease. J. exp. Med.134, pt. 2, 242 s (1971).
McCluskey, R. S., Vassali, P., Gallo, G., Baldwin, D. S.: An immunofluorescent study of pathogenic mechanisms in glomerular diseases. New Engl. J. Med.274, 695 (1966).
Rumpelt, H. J., Thoenes, W.: Fokal-skerosierende Glomerulopathie (Glomerulonephritis) — ein diffuser Prozeß. Klin. Wschr.24, 1143 (1972).
Seegal, B. C., Andres, G. A., Hsu, K. C., Zabriskie, J. B.: Studies on the pathogenesis of acute and progressive glomerulonephritis in man by immunofluorescein and immunoferritin techniques. Fed. Proc.24 (Pt. I), 100 (1965).
Shibata, S., Naruse, T., Miyakawa, Y., Nagasawa, T.: Further purification of the glycoprotein that induces nephrotoxic antibody: Isolation of the active polysaccharide fraction mainly composed of glucose. J. Immunol.104, 215 (1970).
Spiro, R. G.: Studies of the renal glomerular basement membrane. J. biol. Chem.242, 1915 (1967).
Steblay, R. W.: Studies on experimental autoimmune glomerulonephritis: their relevance to human diseases. Int. Convoc. on Immunol., Buffalo, N.Y., 1968, 286. Basel-New York: Karger 1969.
Steblay, R. W., Rudofsky, U.: Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J. Immunol.107, 589 (1971).
Thoenes, G. H., Hammer, D. K.: Immunchemische Untersuchungen am nephrotoxischen Antigen der glomerulären Basalmembran. Clin. chim. Acta18, 253 (1967).
Thoenes, W.: Neuere Aspekte der normalen und pathologischen Feinstruktur des Glomerulus. Mit besonderer Berücksichtigung der chronischen Glomerulonephritis und der Amyloidose. Hippokrates (Stuttg.)16, 609 (1969).
Vernier, R. L.: Glomerulonephritis. In: Textbook of immunopathology, vol. I, p. 365, eds. P. A. Mischer, H. J. Mueller-Eberhard. New York-London: Grune & Stratton 1968.
Willoughby, W. F., Dixon, F. J.: Experimental hemorrhagic pneumonitis produced by heterologous anti-lung antibody. J. Immunol.104, 28 (1970).
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Thoenes, G.H. Die Immunhistologie der Glomerulonephritis. Klin Wochenschr 51, 739–747 (1973). https://doi.org/10.1007/BF01468278
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DOI: https://doi.org/10.1007/BF01468278