Summary
Microscopic sections obtained from paraffin blocks of 30 consecutive neurilemomas stored in 1989 were investigated immunohistochemically with the new monoclonal antibody MIB 1 directed against recombinant parts of Ki-67 antigen. The immunohistochemical staining was carried out on dewaxed microwave-oven-processed paraffin sections of formalin-fixed tumour tissues. The labelling index (LI) obtained was below 1% in 21 cases, 1–3% in 7 cases and more than 3% in 2 cases. There was no correlation between the LI and the age of the patients or the tumour size. The major advantage of MIB 1 over previous immunohistochemical methods is its usefullness in long preserved sections which are ideal for retrospective studies.
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Aguiar, P.H., Tatagiba, M., Dankoweit-Timpe, E. et al. Proliferative activity of acoustic neurilemomas without neurofibromatosis determined by monoclonal antibody MIB 1. Acta neurochir 134, 35–39 (1995). https://doi.org/10.1007/BF01428499
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DOI: https://doi.org/10.1007/BF01428499