Summary
Antibody and cell-mediated immune responses were measured in rabbits immunized with live, UV inactivated herpes simplex virus or with a subunit vaccine containing envelope proteins.
All the types of immunization procedures induced the production of antibody as well as a specific cellular immunity. Furthermore, the subunit vaccine was as effective as the immunization with live or UV inactivated virus to prevent death upon challenge with live HSV.
Live HSV induced a transient unresponsiveness of both B and T cells toin vitro stimulation with various mitogens.
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Cappel, R. Comparison of the humoral and cellular immune responses after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations. Archives of Virology 52, 29–35 (1976). https://doi.org/10.1007/BF01317862
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DOI: https://doi.org/10.1007/BF01317862