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Impaired acid neutralization in the duodenum in pancreatic insufficiency

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Abstract

The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5, and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum.

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Authors and Affiliations

  1. University of Maryland Hospital, 21218, Baltimore, Maryland

    Sudhir K. Dutta MD, Robert M. Russell MD & Frank L. Iber MD

  2. Veterans Administration Medical Center, 3900 Loch Raven Boulevard, 21218, Baltimore, Maryland

    Sudhir K. Dutta MD, Robert M. Russell MD & Frank L. Iber MD

Authors
  1. Sudhir K. Dutta MD
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  2. Robert M. Russell MD
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  3. Frank L. Iber MD
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Supported by the Veterans Administration.

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Dutta, S.K., Russell, R.M. & Iber, F.L. Impaired acid neutralization in the duodenum in pancreatic insufficiency. Digest Dis Sci 24, 775–780 (1979). https://doi.org/10.1007/BF01317211

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  • DOI: https://doi.org/10.1007/BF01317211

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