Abstract
Although the association between acute pancreatitis and pleuropulmonary damage is well documented, so far no information on lung function in patients with chronic pancreatitis is available. In this study functional, radiological, and clinical investigations have been carried out in 42 patients affected by chronic calcific pancreatitis (CCP) and in 50 controls in a case-control study. An impairment of pulmonary diffusing capacity has been detected in CCP patients, while all the parameters of ventilatory function were not different from controls. This finding suggests the presence of early lung parenchymal damage in chronic pancreatitis secondary to either emphysema or pulmonary fibrosis.
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Gambill EE: Pancreatitis. St Louis, CV Mosby, 1973
Imrie CW, Ferguson JC, Murphy D, Blungart LH: Arterial hypoxia in overt pancreatitis. Br J Surg 64:185–188, 1977
Ranson JHC, Ross DF, Fink SD: Early respiratory insufficiency in overt pancreatitis. An Surg 178:75–79, 1973
Berry AR, Taylor TV: Effect of drugs on the pulmonary changes in experimental acute pancreatitis in the rat. Gut 23:481–484, 1982
Ferris BJ: Epidemiology standardization project. Am Rev Resp Dis 118:6–55, 1978
International Labour Office. The ILO U/C international classification of radiographs of the pneumoconiosis. ILO Geneva Occupational Safety and Health series No. 22, 1980
Ogilvie CM, Foster RE, Blakemore WS, Morton JW: A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest 36:1–17, 1957
Cotes JE: Lung Function. Oxford, Blackwell Scientific Publication, 1979, Chap 9–14, 230–250, 329–387
Gadek JE, Hunninghake GW, Fells GA, Zimmerman RL, Keog BA, Crystal RG: Evaluation of the protease antiprotease theory of human destructive lung disease. Bull Eur Physiopathol Respir 16(suppl):27–40, 1980
Lieberman J: Elastase, collagenase, emphysema and alpha1-antitrypsin deficiency. Chest 70:62–67, 1976
Ohlsson K: Neutral leukocyte proteases and elastase inhibited by plasma alpha1-antitrypsin. Scand J Clin Lab Invest 28:251–253, 1971
Gadek JE, Fells GA, Zimmerman RL, Rennard SI, Crystal RG: Antielastase of the human alveolar structures. J Clin Invest 68:889–898, 1981
Cotes JE: Lung Function. Oxford, Blackwell Scientific Publication, 1979, Chap 15, 406–417
Eriksson S: Pulmonary emphysema and alpha1-antitrypsin deficiency. Acta Med Scand 177:175–179, 1964
Borgstrom A, Ohlsson K: Immunoreactive trypsin in serum and peritoneal fluid in acute pancreatitis. Hoppe-Seyler's Z Physiol Chem 359:677–681, 1978
Brodrick JW, Geokas MG, Langman C, Fasset M, Johnson JH: Molecular forms of immunoreactive pancreatic cationic trypsin in pancreatitis patient sera. Am J Physiol 237:e474-e480, 1979
Kuhn C III, Slodkowska J, Smith T, Starcher B: The tissue response to exogenous elastase. Bull Eur Physiopathol Respir 16(suppl):127–137, 1980
Senior RM, Bielefeld DR, Starcher BC: Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase. Biochem Biophys Res Commun 72:1327–1334, 1976
Kaplan PD, Kuhn C, Pierce JA: The induction of emphysema with elastase. J Lab Clin Med 82:349–354, 1973
Schuyler MR, Rynbrandt DJ, Kleinerman J: Physiologic and morphologic observation of the effects of intravenous elastase on the lung. Am Rev Respir Dis 117:97–102, 1978
Balldin G, Ohlsson K: Demonstration of pancreatic protease-antiprotease complexes in the peritoneal fluid of patients with acute pancreatitis. Surgery 85:451–456, 1979
Eddeland A, Ohlsson K: Release of proteolytic enzymes in bile induced pancreatitis in dogs. Gastroenterology 69:668–675, 1975
Borgstrom A, Kukora J, Ohlsson K: Studies on immunoreactive pancreatic elastase 2 in human serum. Hoppe-Seyler's Z Physiol Chem 361:633–640, 1980
Satake K, Tei Y, Yoshimoto T, Umeyama K, Ohyama T: Plasma elastase levels in rats with various pancreatic disease by radioimmunoassay.In American Pancreatic Association Chicago, 1980 (abstract)
Harel S, Yu SY, Janoff A, Hurewitz A, Bergofsky A: Measurement of elastin degradationin vivo by desmosine radioimmunoassay. Bull Eur Physiopathol Respir 16(suppl):75–81, 1980
Gullo L, Stella A, Labriola E, Costa P, Descovich G, Labo G: Cardiovascular lesions in chronic pancreatitis. Dig Dis Sci 27:716–722, 1982
Balo J, Banga I: Change in the elastase content of the human pancreas in relation to arteriosclerosis. Acta Physiol Acad Sci Hung 4:187–194, 1953
El-Ridi S, Hall DA: Isolation of elastase from human serum.In Biochemical Society Transactions, 561 st Meeting, Leeds, 1976, pp 336–337
Lee BC, Malik AB, Barie PS, Minnear FL: Effect of acute pancreatitis on pulmonary transvascular fluid and protein exchange. Am Rev Respir Dis 123:618–621, 1981
Kwann HC, Anderson MC, Gramatica L: A study of pancreatic enzymes as a factor in the pathogenesis of disseminated intravascular coagulation during acute pancreatitis. Surgery 69:663–672, 1973
Lankisch PJ, Rahlf G, Koop H: Pulmonary complications in fatal acute hemorrhagic pancreatitis. Dig Dis Sci 28:111–116, 1983
Interiano B, Stuard D, Hyde RW: Acute respiratory distress syndrome in pancreatitis. Ann Intern Med 77:923–926, 1972
Lebowitz MD: Respiratory symptoms and disease related to alcohol consumption. Am Rev Respir Dis 123:16–19, 1981
Cohen BH, Celetano CD, Chase GA, Diamond EL, Graves CG, Levy DA, Menkes HA, Meyer MB, Permutt S, Tockman MS: Alcohol consumption and airway obstruction. Am Rev Respir Dis 121:205–215, 1980
Banks PA: Pancreatitis. New York, Plenum Medical, 1979
McKenna JM, Chandrasekhar AJ, Skorton D, Craig RM, Cugell DW: The pulmonary complications of pancreatitis. Chest 71:197–204, 1977
Robinette CD, Fraumeni JF: Asthma and subsequent mortality in World War II veterans. J Chron Dis 31:619–624, 1978
Sarles H, Sarles JC, Camatte R, Muratore R, Gaini N, Guien C, Pastor J, Le Roy J: Observations on 205 confirmed cases of acute pancreatitis, recurrent pancreatitis and chronic pancreatitis. Gut 6:545–559, 1965
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Masoero, G., Spinaci, S., Arossa, W. et al. Pulmonary involvement in chronic pancreatitis. Digest Dis Sci 29, 896–901 (1984). https://doi.org/10.1007/BF01312477
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DOI: https://doi.org/10.1007/BF01312477