Abstract
The amino acid sequence (1–21) of glucagon has been shown to have full spasmolytic action in animal studies but no metabolic effect. The motor activity of the sphincter of Oddi was measured during ERCP with manometric recordings of sphincter pressure. Then glucagon-(1–21)-peptide was given as a bolus intravenous injection; serial blood samples were taken to determine glucagon-like immunoreactivity. The spasmolytic effect of glucagon-(1–21)-peptide began 15 sec after injection and lasted up to 22 min at the higher doses. The basal pressure of the sphincter of Oddi was decreased by 31–56% after administration of glucagon-(1–21)-peptide. Phasic sphincter of Oddi pressure and wave frequency were also affected. In conclusion, glucagon-(1–21)-peptide has a relaxing effect on the human sphincter of Oddi and might emerge as an alternative to glucagon or other spasmolytic drugs for obtaining selective relaxation of the biliary tract.
Similar content being viewed by others
References
Bonfils S, Gislon J, Galmiche JP: Manométrie biliaire postopératoire sous perfusion intracholédocienne à débuts variés avec ou sans administration de morphine. Biol Gastroenterol 7:117–129, 1974
Nebel OT: Manometric evaluation of the papilla of Vater. Gastrointest Endosc 21:126, 1975
Geenen JE, Hogan WJ, Dodds WJ, Stewart ET, Arndorfer RC: Intraluminal pressure recording from the human sphincter of Oddi. Gastroenterology 78:317–324, 1980
Schaffer RD, Hogan WJ, Geenen JE, Dodds WJ, Stewart ET, Arndorfer RC: Sphincter of Oddi motor activity: Demonstration of unique high-pressure phasic contractions. Gastroenterology 72:1130, 1977
Carr-Locke DL, Gregg JA: Endoscopic manometry of pancreatic and biliary sphincter zones in man. Dig Dis Sci 26:7–15, 1981
Rey JF, Corallo J, Lombart J, Pangtay-Tea J: The use of endoscopic manometry to demonstrate the effect of glucagon on the sphincter of Oddi.In Glucagon in Gastroenterology and Hepatology. J Picazo (ed). Lancaster. MTP Press, 1982, pp 99–113
Diamant B, Picazo J: Spasmolytic action and clinical use of glucagon.In Handbook of Experimental Pharmacology, Vol 66/2 Glucagon. PJ Lefebvre (ed). Berlin, Springer, 1983, pp 611–643
Jensen DM, Tapia JI, Beilin DB, Weiss S: Control of motility and pressures of the human sphincter of Oddi. Gastroenterology 82:1093, 1982
Carr-Locke DL, Gregg JA, Aoki TT: Effects of exogenous glucagon on pancreatic and biliary ductal and sphincteric pressures in man demonstrated by endoscopic manometry and correlation with plasma glucagon. Dig Dis Sci 28:312–320, 1983
Rey JF, Lombart J: Endoscopic demonstration of the use-fulness of glucagon and 1–21 glucagon on the sphincter of Oddi. Acta Endosc 13:117–124, 1983
Diamant B, Jørgensen KD, Weis JU: Structure-activity relationship for the spasmolytic action of glucagon.In Glucagon in Gastroenterology and Hepatology. J Picazo (ed). Lancaster, MIT Press, 1982, pp 25–36
Jørgensen KD, Weis JU, Diamant B: Dissociation of the spasmolytic and metabolic effects of glucagon. Eur J Pharmacol 90:315–323, 1983
Tanaka M, Ikeda S, Nakayama F: Nonoperative measurement of pancreatic and common bile duct pressures with a microtransducer catheter and effects of endoscopic sphincterotomy. Dig Dis Sci 26:545–552, 1981
Bortolloti M, Caletti GC, Brocchi E, Foschi S, Lorganesi A, Guizzardi G, Labo G: Manometric and electromyographic studies of the sphincter of Oddi in man. Gut 23:A-370, 1983
Ponce J, Sala T, Pertejo V, Pina R, Berenguer J: Effect of glucagon applied topically in the duodenum on the motor activity of the sphincter of Oddi. Acta Endosc 13:131–138, 1983
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rey, J.F., Greff, M. & Picazo, J. Glucagon-(1–21)-peptide. Digest Dis Sci 31, 355–360 (1986). https://doi.org/10.1007/BF01311669
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01311669