Abstract
We have investigated the gastric secretory activity and the emptying half-time of a liquid meal in 17 selected patients with reflux esophagitis compared to 10 controls. The basal acid output and the basal and maximal secretory volume were higher in the patient group (P<0.05,P=0.05, andP<0.01, respectively), while the maximal acid output and the basal and maximal acid concentration were not different in the two groups. The gastric emptying half-time of a liquid meal was higher in the patient group (P<0.001). Our results show that gastric function may be altered in reflux esophagitis patients and suggest particularly that a delayed emptying of liquids may play a role in the pathogenesis of the disease in some patients.
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References
Thurer RL, De Meester TR, Johnson LF: The distal esophageal sphincter and its relationship to gastroesophageal reflux. J Surg Res 16:418–423, 1974
Bennett JR: The physician's problem. Gut 14:246–249, 1973
Behar J, Biancani P, Sheehan DG: Evaluation of esophageal tests in the diagnosis of reflux esophagitis. Gastroenterology 71:9–15, 1976
Krejs GJ, Seefeld U, Braendli HH, Bron BA, Caro G, Schmid P, Blum AL: Gastro-esophageal reflux disease: correlation of subjective symptoms with 7 objective oesophageal function tests. Acta Hepato-Gastroenterol 23:130–140, 1976
Booth DJ, Kemmerer WT, Skinner DB: Acid clearing from the distal esophagus. Arch Surg 96:731–734, 1968
Stol DW, Murphy GM, Collis JL: Duodeno-gastric reflux and acid secretion in patients with symptomatic hiatal hernia. Scand J Gastroenterol 9:97–101, 1974
Boesby S: Relationship between gastro-oesophageal acid reflux, basal gastro-oesophageal sphincter pressure and gastric acid secretion. Scand J Gastroenterol 12:547–551, 1977
Gillison EW, Nyhus LM, Duthie HL: Bile reflux, gastric secretion and heartburn. Br J Surg 58:864–870, 1971
Behar J, Ramsby G: Gastric emptying and antral motility in reflux esophagitis. Gastroenterology 74:253–256, 1978
Csendes A, Henriquez A: Gastric emptying in patients with reflux esophagitis or benign strictures of the esophagus secondary to reflux compared to controls. Scand J Gastroenterol 13:205–207, 1978
Coleman SL, Rees WDW, Malagelada JR: Normal gastric function in reflux esophagitis. Gastroenterology 76:1115(A), 1979
Donovan IA, Harding LK, Keighley MRB, Griffin DW, Collis JL: Abnormalities of gastric emptying and pyloric reflux in uncomplicated hiatus hernia. Br J Surg 64:847–848, 1977
Pope CE II: Mucosal response to esophageal motor disorders. Arch Intern Med 136:549–555, 1976
Ostick DG, Green G, Howe K, Dymock IW, Cowley DJ: Simple clinical method of measuring gastric emptying of solid meals. Gut 17:189–191, 1976
Abraham GE: Counting statistical theory. Handbook of Radioimmunoassay. New York, Marcel Dekker, 1977, pp 71–78
Grimes D, Goddard J: Effect of cigarette smoking on gastric emptying. Br Med J 2:460–461, 1978
Corinaldesi R, Fabbri R, Salera M, Venturoli L, Barbara L: Studio del tempo di svuotamento gastrico con tecnica radio-isotopica in corso di somministrazione di cimetidina.In Cimetidina: Farmacologia e clinica, PE Lucchelli (ed). Milano, Smith, Kline and French, 1978, pp 127–134
Crumplin MKH, Stol DW, Murphy GM, Collis JL: The pattern of bile salt reflux and acid secretion in sliding hiatal hernia. Br J Surg 61:611–616, 1974
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Baldi, F., Corinaldesi, R., Ferrarini, F. et al. Gastric secretion and emptying of liquids in reflux esophagitis. Digest Dis Sci 26, 886–889 (1981). https://doi.org/10.1007/BF01309491
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DOI: https://doi.org/10.1007/BF01309491