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Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally

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Abstract

The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a meal is reversed by cisapride and thus could serve as a model for such evaluations. Twelve healthy males received, under double-blind conditions, 30 mg cisapride rectally or placebo, and 3 hr thereafter a semisolid meal of low (9.2 g) or high (37.9 g) fat content. The sequence of combinations placebo/low-fat meal, placebo/high-fat meal, and cisapride/high-fat meal was randomized. Gastric emptying and antral motility were recorded scintigraphically. After placebo/high-fat, emptying was significantly slower (P<0.05) than after placebo/low-fat. After cisapride/high-fat, emptying was significantly faster (P<0.01) than after placebo/high-fat and similar to that after placebo/low-fat. Antral motility was little affected. The slow emptying of a high-fat meal thus seems a suitable model for the evaluation of prokinetic drug effects.

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Authors and Affiliations

  1. Psychophysiology Unit at the Departments of Psychiatry and Surgery I; Division of Nuclear Medicine of the Department of Medicine II: Ludwig Boltzmann Institute of Nuclear Medicine Psychophysiologisches Laboratorium, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    G. Stacher MD, G. V. Granser MD, H. Bergmann PhD, A. Kugi MA, G. Stacher-Janotta & J. Höbart BEng

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  1. G. Stacher MD
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  2. G. V. Granser MD
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  3. H. Bergmann PhD
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  4. A. Kugi MA
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  5. G. Stacher-Janotta
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  6. J. Höbart BEng
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Stacher, G., Granser, G.V., Bergmann, H. et al. Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally. Digest Dis Sci 36, 1259–1265 (1991). https://doi.org/10.1007/BF01307519

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  • DOI: https://doi.org/10.1007/BF01307519

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