Abstract
Fractional hepatic extraction of gastric inhibitory polypeptide was examined in conscious unrestrained dogs with catheters in the portal vein, hepatic vein, and the carotid artery and Doppler flow probes on the portal vein and hepatic artery. Following a control period, endogenous gastric inhibitory polypeptide was stimulated by oral administration of glucose with and without prior infusion of atropine. In other experiments, gastric inhibitory polypeptide (20 ng/kg/min) was infused into the portal system in association with peripheral infusion of glucose. In none of these experiments was it possible to demonstrate any significant fractional hepatic extraction of gastric inhibitory polypeptide.
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This work was supported by USPHS grant AM 25253 and the Diabetes and Endocrinology Research Center grant AM 27685 Baylor College of Medicine, and The Clinical Research Center Core Laboratory (NIH, GCRC, RR-34) of the Ohio State University Hospital.
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Chap, Z., O'Dorisio, T.M., Cataland, S. et al. Absence of hepatic extraction of gastric inhibitory polypeptide in conscious dogs. Digest Dis Sci 32, 280–284 (1987). https://doi.org/10.1007/BF01297054
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DOI: https://doi.org/10.1007/BF01297054