Abstract
Plasma concentrations of motilin rise in the first 30 min following the ingestion of a meal in man. To elucidate the mechanisms of this postprandial motilin release, we verified the effect of cerebral stimulation and of gastric distension, both events normally occurring in the early postprandial period, on plasma motilin concentrations. Cerebral stimulation was induced by modified sham feeding (MSF) and gastric distension was done by inflating (with 0, 60, 240, or 480 cc of air) a latex balloon positioned in the gastric fundus. The experiments were performed in healthy volunteers where antroduodenal contractile activity was continuously recorded and where plasma motilin was measured each 10 min. The stimuli were administered 30 min after a phase III of the migrating motor complex (MMC) was seen migrating from the antrum to the duodenum. The interval period between two successive spontaneous peak increases in plasma motilin was estimated at 113.7±8.5 min in 24 historical control subjects, and it lasted 97±13 min in the five control volunteers here distended with 0 cc of air (P=NS). This interval was significantly (P<0.05) shortened with MSF (70±6.3 min) or following distension with 60 cc (60±11.4 min), 240 cc (54±1.9 min) or 480 cc of air (45±3.2 min). During the 60-min period following the administration of the stimuli, phase IIIs were not seen in the subjects distended with 0 cc of air or in those submitted to MSF. However, balloon distension with 60, 240, or 480 cc of air elicited a premature phase III migrating from the antrum to the duodenum in 3/5, 5/5, and 5/5 of the tested subjects respectively. We conclude that cerebral stimulation by MSF and gastric distension by air-filled balloons were potent stimuli of motilin release, and we therefore suggest that both stimuli could be involved in the process of plasma motilin increase seen after a meal. However, MSF and gastric distension probably acted on different additional modulators since they had opposite effects on antroduodenal motility.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Poitras P, Trudel L, Lahaie RG, Pomier Layrargues G: Motilin-like immunoreactivity in intestine and brain of dog. Life Sci 42:1391–1395, 1987
Bloom SR, Polak JM: Gut hormone overview.In Gut Hormones. SR Bloom (ed), Edinburgh, Churchill Livingston, 1978, pp 3–17
Poitras P: Motilin is a digestive hormone in the dog. Gastroenterology 87:909–913, 1984
Lee KY, Chang TM, Chey WY: Effect of rabbit anti-motilin serum on myoelectrical activity and plasma motilin concentration in fasting dog. Am J Physiol 245:G547-G553, 1983
Boivin M, Raymond MC, Riberdy M, Trudel L, St-Pierre S, Poitras P: Plasma motilin variation during the interdigestive and digestive states in man. J Gastrointest Motil 2:240–246, 1990
Bormans V, Peeters TL, Janssens J, Pearce D, Vanderweerd M, Vantrappen G: In man, only activity fronts that originate in the stomach correlate with motilin peaks. Scand J Gastroenterol 22: 781–784, 1987
Poitras P, Steinbach JH, Van Deventer G, Code CF, Walsh JH: Motilin independent ectopic fronts of the interdigestive myoelectrical complex in dogs. Am J Physiol 239:G215-G220, 1984
Christofides ND, Bloom SR, Vantrappen G, Janssens J, Peeters TL, Hellemans J: Postprandial release of motilin in relation to the interdigestive motor complex in man. Biomed Res 2:67–68, 1981
Christofides ND, Bloom SR, Besterman HS: Release of motilin by oral and intravenous nutrients in man. Gut 20:102–106, 1979
Thompson DG, Wingate DL, Archer L, Benson MJ, Green WJ, Hardy RJ: Normal patterns of human upper small-bowel motor activity recorded by prolonged radiotelemetry. Gut 21:500–506, 1980
Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC: Human interdigestive motility: Variations in patterns from esophagus to colon. Gastroenterology 91:386–395, 1986
Rees WDW, Malagelada JR, Miller LJ, Go VLW: Human interdigestive and postprandial gastrointestinal motor and gastrointestinal hormone patterns. Dig Dis Sci 27:321–329, 1982
Kerlin P, Phillips S: Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 82:694–700, 1982
Vantrappen G, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977
Lee KY, Chey WY: Endogenous motilin release: Physiology and pathophysiology.In Motilin. Z Itoh (ed). San Diego, Academic Press, 1990, pp 169–184
Diamant NE: Mechanisms of motilin release by luminal stimuli and vagal nerve.In Motilin. Z Itoh (ed). San Diego, Academic Press, 1990, pp 191–208
Jarhult J, Graffner H, Bloom SR: The influence of modified sham feeding on plasma polypeptide concentrations in duodenal ulcer patients. Acta Chir Scand 150:141–144, 1984
Klajner F, Herman CP, Polivy J, Marliss EB, Greenberg GR: Increased postprandial motilin response in lean and obese dieters. Gastroenterology 80:1192, 1981
Rogers J, Raymondo AH, Miziewics JJ, Bloom SR: Cephalic phase of PP, motilin and gastrin release is associated with the cephalic phase of the colonic response to food. Gastroenterology 98:385, 1990
Peeters TL, Vantrappen G, Janssens J: Sham feeding amplified the secretory component of interdigestive activity. Gastroenterology 84:1272, 1983
Azpiroz F, Malagelada JR: Gastric tone measured by an electronic barostat in health and postsurgical gastroparesis. Gastroenterology 92:934–943, 1987
Author information
Authors and Affiliations
Additional information
Supported by the Medical Council of Canada (MA8732) and the Fondation de l'Hôpital Saint-Luc.
Rights and permissions
About this article
Cite this article
Boivin, M., Bradette, M., Raymond, M.C. et al. Mechanisms for postprandial release of motilin in humans. Digest Dis Sci 37, 1562–1568 (1992). https://doi.org/10.1007/BF01296503
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296503