Abstract
We investigated the effects of total abdominal fractionated irradiation on postprandial small intestinal motor activity in five dogs. Five strain-gauge transducers were attached to the seromuscular layer of the duodenum, jejunum, and ileum of each dog to record circular muscle contractions. Radiation (250 cGy) was administered three times a week on alternate days for three successive weeks (total dose, 2250 cGy). Postprandial 4-hr recordings were made once each week during radiation and at one and three weeks following completion of radiation. Duodenal mean amplitude and area under contractions did not change during or following the radiation schedule, but the mean frequency and duration of duodenal contractions decreased during the radiation schedule. Both parameters returned to baseline values postirradiation. Jejunal mean duration, amplitude, area, and frequency of contractions decreased during radiation; mean amplitude and area returned to baseline values postirradiation but not the duration and frequency of contractions. All parameters of ileal contractions decreased during radiation, and all but area and amplitudes remained depressed postirradiation. Significantly decreased strength and frequency of contractions, particularly in the jejunum and ileum occur during and following irradiation. These changes may potentially alter transit time.
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Otterson MF, Sarna SK, Moulder JE: Effects of therapeutic doses of ionizing radiation on small intestinal motor activity. Gastroenterology 95:1249–1257, 1988
Summers RW, Flatt AJ, Prihoda MJ, Mitros FA: Effect of irradiation on morphology and motility of canine small intestine. Dig Dis Sci 32:1402–1410, 1987
Sarna SK: Giant migrating contractions and their myoelectric correlates in the small intestine. Am J Physiol 253:G697-G705, 1987
Sarna SK, Otterson MF: Small intestinal physiology and pathophysiology. Gastroenterol Clin North Am 18:375–404, 1989
Kerlin P, Zinmeister A, Phillips S: Relationship of motility of flow of contents in the human small intestine. Gastroenterology 82:701–706, 1982
Kellow JE, Phillips SF: Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 92:1885–1893, 1987
Sarna SK, Soergel KH, Harig JM, Loo FD, Wood CM, Donahue KM, Ryan RP, Arndorfer R: Spatial and temporal patterns of human jejunal contractions. Am J Physiol 257:G423-G432, 1989
Cowles VE, Sarna SK: Effect of cholera toxin on small intestinal motor activity in the fed state. Dig Dis Sci 35:353–359, 1990
Cowles VE, Sarna SK: Trichinella spiralis infection alters small bowel motor activity in the fed state. Gastroenterology 101:664–669, 1991
Schemann M, Ehrlein HJ: Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology 90:991–1000, 1986
Summers RW, Dusdieker NS: Patterns of spike burst spread and flow in the canine small intestine. Gastroenterology 81:742–750, 1981
Read NW, Al-Janabi MN, Edwards CA, Barber DC: Relationship between postprandial motor activity in the human small intestine and the gastrointestinal transit of food. Gastroenterology 86:721–727, 1984
Sarna SK: In vivo myoelectric activity: Methods, analysis, and interpretation.In Handbook of Physiology, Gastrointestinal Motility and Circulation. JD Wood (ed). American Physiology Society, Bethesda, Maryland, 1989, pp 817–863
Cowles VE, Condon RE, Schulte WJ, Woods JH, Sillin LF: A quarter wheatstone bridge strain gauge force transducer for recording gut motility. Am J Dig Dis 23:936–939, 1978
Sarna SK, Condon RE, Cowles VE: Morphine versus motilin in the initiation of migrating myoelectric complexes. Am J Physiol 245:G217-G220, 1983
Mettler FA: Effects of whole-body irradiation.In Medical Management of Radiation Accidents. FA Mettler, CA Kelsey, RC Ricks (eds). Boca Raton, Florida, CRC Press, 1990, pp 79–88
Kinsella TJ, Bloomer WD: Tolerance of the intestine to radiation therapy. Surg Gynecol Obstet 151:273–284, 1980
Tarpila S: Morphological and functional response of the human small intestine mucosa to ionizing radiation. Scand J Gastroenterol 6(suppl 12)1–52, 1971
Trier JS, Browning TH: Morphologic response of the mucosa of the human small intestine to x-ray exposure. J Clin Invest 45:194–204, 1966
Wiernik G: Radiation damage and repair in the human jejunal mucosa. J Pathol Bacteriol 91:389–393, 1966
Perino LE, Schuffler MD, Mekta SJ, Everson GT: Radiation-induced intestinal pseudoobstruction. Gastroenterology 91:994–998, 1986
Buell MG, Harding RK: Proinflammatory effects of local abdominal irradiation in rat gastrointestinal tract. Dig Dis Sci 34:390–399, 1989
Summers RW, Kent TH, Osborne JW: Effect of drugs, ileal obstruction and irradiation on rat gastrointestinal propulsion. Gastroenterology 59:731–739, 1970
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Supported in part by NIDDK grants DK43104 to Dr. M.F. Otterson and DK32346 to Dr. S.K. Sarna.
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Otterson, M.F., Sarna, S.K. & Lee, M.B. Fractionated doses of ionizing radiation alter postprandial small intestinal motor activity. Digest Dis Sci 37, 709–715 (1992). https://doi.org/10.1007/BF01296427
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DOI: https://doi.org/10.1007/BF01296427