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Augmentation of postresection mucosal hyperplasia by plerocercoid growth factor (PGF)

Analog of human growth hormone

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Abstract

Postresection villus hyperplasia is a major compensatory mechanism in the short-bowel patient. Substances capable of augmenting postresection mucosal hyperplasia could have therapeutic implications. Human growth hormone (hGH) and human growth hormone releasing factor (hGHRF) stimulate growth of the gastrointestinal tract; however, the diabetogenic actions of growth hormone limit its usefulness in clinical practice. Plerocercoid larvae of the tapewormSpirometra mansonoides produce an analog of hGH void of diabetogenic side effects. We assessed effects of plerocercoid growth factor (PGF) on mucosal adaptation following 70% proximal jejunoileal resection in young rats. Mucosal weight, DNA, protein, and total sucrase activity per centimeter of bowel were increased in resected PGF-treated animals compared to resected controls. We conclude PGF augments intrinsic postresection mucosal hyperplasia following extensive intestinal resection.

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Authors and Affiliations

  1. Departments of Pediatrics, Medicine, and Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska

    Michael H. Hart MS, MD, C. K. Phares PhD, Steven H. Erdman MD, Carter J. Grandjean PhD, Jung H. Y. Park PhD & Jon A. Vanderhoof MD

  2. Swanson Center for Nutrition, Inc., 502 South 44 Street, 68105, Omaha, Nebraska

    Michael H. Hart MS, MD, C. K. Phares PhD, Steven H. Erdman MD, Carter J. Grandjean PhD, Jung H. Y. Park PhD & Jon A. Vanderhoof MD

Authors
  1. Michael H. Hart MS, MD
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  2. C. K. Phares PhD
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  3. Steven H. Erdman MD
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  4. Carter J. Grandjean PhD
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  5. Jung H. Y. Park PhD
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  6. Jon A. Vanderhoof MD
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Hart, M.H., Phares, C.K., Erdman, S.H. et al. Augmentation of postresection mucosal hyperplasia by plerocercoid growth factor (PGF). Digest Dis Sci 32, 1275–1280 (1987). https://doi.org/10.1007/BF01296378

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  • DOI: https://doi.org/10.1007/BF01296378

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