Skip to main content
Log in

Dysplastic gangliocytoma of the cerebellum—An ultrastructural study

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

A case of dysplastic gangliocytoma of the cerebellum, a rare disorder with unknown etiology and pathogenesis, was studied ultrastructurally. The intranuclear inclusions identified were not seen to be of viral origin. The ultrastructural characteristics of the abnormal cells support the prevailing theory that these cells represent hypertrophied granular neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ambler, M., Pogacar, S., Sidman, R.: Lhermitte-Duclos disease (granule cell hypertrophy of the cerebellum). Pathological analysis of the first familial cases. J. Neuropath. exp. Neurol.28, 622–647 (1969)

    Article  CAS  PubMed  Google Scholar 

  • Christensen, E.: Über Ganglienzellgeschwülste im Gehirn. Virchows Path. Anat.300, 567–581 (1937)

    Article  Google Scholar 

  • Courville, C. B.: Gangliocytoma myelinicum diffusum of the cerebellar cortex. Bull. Los Angeles Neurol. Soc.23, 72–80 (1958)

    CAS  PubMed  Google Scholar 

  • Duncan, D., Snodgrass, S. R.: Diffuse hypertrophy of the cerebellar cortex (myelinated neurocytoma). Arch. Neurol. Psychiat.50, 677–684 (1943)

    Article  Google Scholar 

  • Foerster, O., Gagel, O.: Ein Fall von Gangliocytoma dysplasticum des kleinhirns. Ztschr. f. d. ges. Neurol. u. Psychiat.146, 792–803 (1933)

    Article  Google Scholar 

  • Hallervorden, J.: Über die Hamartome (Ganglioneurome) des Kleinhirns. Dtsch. Ztschr. Nervenhk.179, 531–563 (1959)

    CAS  Google Scholar 

  • Lhermitte, J., Duclos, P.: Sur un ganglioneuroma diffus du cortex du cervelet. Bull. Assoc. Franç. Cancer9, 99–107 (1920)

    Google Scholar 

  • Oppenheimer, D. R.: A benign “tumour” of the cerebellum. Report on two cases of diffuse hypertrophy of the cerebellar cortex with a review of nine previously reported cases. J. Neurol. Neurosurg. Psychiat.18, 199–213 (1955)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Peters, A., Palay, S. L., Webster, H. de F.: The fine structure of the nervous system: The neurons and supporting cells, 2nd ed. Philadelphia-London-Toronto: W. B. Saunders Company 1976

    Google Scholar 

  • Ramon y Cajal, S.: In studies on vertebrate neurogenesis, translated by L. Guth, 1 ed. Springfield: Charles C. Thomas 1960

    Google Scholar 

  • Rubinstein, L. J.: Tumors of the central nervous system, atlas of tumor pathology, Fascicle 6, Second series. Washington: Armed Forces Institute of Pathology 1972

    Google Scholar 

  • Russell, D. S., Rubinstein, L. J.: Pathology of tumours of the nervous system, 4 ed. Baltimore: The Williams and Wilkins Company 1977

    Google Scholar 

  • Simeoni, S.: II gangliocitoma displastico del cervelleto. Giorn. Ital. di Patologia e Scienze Affini13, 1–46 (1966)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pritchett, P.S., King, T.I. Dysplastic gangliocytoma of the cerebellum—An ultrastructural study. Acta Neuropathol 42, 1–5 (1978). https://doi.org/10.1007/BF01273258

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01273258

Key words

Navigation