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Antagonism by baclophen of thed-amphetamine-induced disruption of a successive discrimination in the rat

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Summary

Male rats were trained to perform a conditioned avoidance response combined with a successive discrimination in a shuttle-box. The administration ofd-amphetamine, 4 mg/kg i.p., caused a disruption of the discriminative but not the avoidance behaviour. Baclophen (β-[-4-chlorophenyl]-γ-aminobutyric acid), a GABA-derivative, given in a dose (4 mg/ kg i.p.) that had no effectper se on the behaviour in this test situation antagonized thed-amphetamine-induced abnormal behaviour without affecting thed-amphetamine-induced hypermotility.

The present findings that baclophen antagonized a biochemically induced abnormal behaviour point to an “antipsychotic” action of baclophen in a successive discrimination avoidance test.

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Author notes

  1. J. Engel

    Present address: Department of Pharmacology, University of Göteborg, Göteborg, Sweden

Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, Göteborg, Sweden

    S. Ahlenius & A. Carlsson

Authors
  1. S. Ahlenius
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  2. A. Carlsson
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  3. J. Engel
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Ahlenius, S., Carlsson, A. & Engel, J. Antagonism by baclophen of thed-amphetamine-induced disruption of a successive discrimination in the rat. J. Neural Transmission 36, 327–333 (1975). https://doi.org/10.1007/BF01253132

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  • DOI: https://doi.org/10.1007/BF01253132

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