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Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine Levels in human basal ganglia

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Summary

The caudate nuclei and putamens of 30 human brains were analyzed for dopamine and its metabolite 3-methoxytyramine, most of which was presumably formed from dopamine postmortally. It was found that dopamine and the sum (dopamine + methoxytyramine) but not methoxytyramine declined with the time interval between death and autopsy as well as with age.

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Author notes

  1. A. Carlsson

    Present address: Department of Pharmacology, University of Göteborg, Sweden

Authors and Affiliations

  1. Department of Pathology, University of Umeå, Sweden

    B. Winblad

Authors
  1. A. Carlsson
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  2. B. Winblad
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Dedicated to Prof. Dr.W. Birkmayer on the occasion of his 65th birthday.

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Carlsson, A., Winblad, B. Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine Levels in human basal ganglia. J. Neural Transmission 38, 271–276 (1976). https://doi.org/10.1007/BF01249444

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  • DOI: https://doi.org/10.1007/BF01249444

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