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Metal speciation in biological fluids — a review

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Abstract

The literature on the speciation of metal ions in biological fluids is comprehensively reviewed. Critical examination on this subject reveals that major work has been done in blood and urine. Speciation in materials like milk has not yet been widely studied. On the other hand, only few references could be found on sweat, saliva, cell lysate, cerebrospinal, seminal, tear and bronchoalveolar fluids. The topics studied for these fluids were mainly the speciation of arsenic, mercury, aluminium and selenium. Work on the speciation of other elements like zinc, chromium, cadmium, lead, copper, iron etc. have also been carried out in such matrices. The present literature survey includes also a critical comment about the sampling and storage of the fluids, general methodologies and analytical details of the developed methods for studying such metal ion speciation.

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References

  1. I. S. Krull (ed.),Journal of Chromatography Library, Vol. 47, Elsevier, Amsterdam, 1991.

    Google Scholar 

  2. R. Cornells, J. Dekimpe,J. Anal. At. Spectrom. 1994,9, 945.

    Google Scholar 

  3. A. K. Das, R. Chakraborty, M. L. Cervera, M. de la Guardia,Talanta 1995,42, 1007.

    Google Scholar 

  4. R. Cornells, F. Borguet, J. Dekimpe,Anal. Chim. Acta. 1993,283, 183.

    Google Scholar 

  5. L. Dunemann,Fresenius J. Anal. Chem. 1992,342, 802.

    Google Scholar 

  6. P. E. Gardiner,J. Anal. At. Spectrom. 1988,3, 163.

    Google Scholar 

  7. P. E. Gardiner,J. Anal. At. Spectrom. 1993,345, 287.

    Google Scholar 

  8. D. Behne,Analyst 1992,117, 555.

    Google Scholar 

  9. J. C. Van Loon, R. R. Barefoot,Analyst 1992,117, 563.

    Google Scholar 

  10. H. J. Robberecht, H. A. Deelstra,Talanta 1984,31, 497.

    Google Scholar 

  11. N. Violante, G. Carelli, S. Caroli,Ann. Ist. Super. Sanita,1989,25, 499.

    Google Scholar 

  12. N. P. Vela, L. K. Olson, J. A. Caruso,Anal. Chem. 1993,65, 585A.

    Google Scholar 

  13. J. B. Dawson,Fresenius Z. Anal. Chem. 1986,324, 463.

    Google Scholar 

  14. D. Behne,J. Clin. Chem. Clin. Biochem. 1981,19, 115.

    Google Scholar 

  15. J. R. W. Woittiez, H. T. Wolterbeek, G. J. van den Berg, O. M. Steinebach,6th International Workshop on Trace Element Analytical Chemistry in Medicine and Biology, Munich/Neuherberg, Germany, April 24–26, 1991.

    Google Scholar 

  16. M. Horvat, A. R. Byrne,Analyst 1992,117, 665.

    Google Scholar 

  17. M. H. Kroll, R. Chester, R. J. Elin,Clin. Chem. 1989,35, 1523.

    Google Scholar 

  18. N. W. Alcock,Anal. Chem. 1993,65, 463A.

    Google Scholar 

  19. M. de la Guardia, in:Element Speciation in Bioinorganic Chemistry (S. Caroli, ed.), Wiley, New York, 1995.

    Google Scholar 

  20. M. L. Lee, K. E. Markides,Analytical Supercritical Fluid Chromatography and Extraction, Chromatography Conferences, Provo, UT, 1990.

  21. W. Lund,Fresenius J. Anal. Chem. 1990,337, 557.

    Google Scholar 

  22. F. J. Fernández,At. Abs. Newslett. 1977,16, 33.

    Google Scholar 

  23. L. Ebdon, S. J. Hill, R. W. Ward,Analyst 1986,111, 1113.

    Google Scholar 

  24. Y. K. Chau, P. T. S. Wong, in:Trace Element Speciation: Analytical Methods And Problems (G. E. Batley, ed.), CRC, Boca Raton, FL, 1989, pp. 219–244.

    Google Scholar 

  25. L. Ebdon, S. Hill, R. W. Ward,Analyst 1987,112, 1.

    Google Scholar 

  26. K. J. Irgolic,Sci. Tot. Environ. 1987,64, 61.

    Google Scholar 

  27. L. Ebdon, S. Hill, A. P. Walton, R. W. Ward,Analyst 1988,113, 1159.

    Google Scholar 

  28. D. R. Jones IV, S. E. Managhan,Anal Chem. 1976,48, 1887.

    Google Scholar 

  29. G. E. Parris, W. R. Blair, F. E. Brinckman,Anal. Chem. 1977,49, 378.

    Google Scholar 

  30. L. Ebdon, R. W. Ward, D. A. Leathard,Analyst 1982,107, 129.

    Google Scholar 

  31. G. M. Momplaisir, J.-S. Biais, M. Quinteiro, W. D. Marshall,J. Agric. Food Chem. 1991,39, 1448.

    Google Scholar 

  32. R. Muñoz Olivas, O. F. X. Donard, C. Cámara, P. Quevauviller,Anal. Chim. Acta 1994,286, 357.

    Google Scholar 

  33. J. Gui-Bin, N. Zhe-Ming, W. Shun-Rong, H. Heng-Bin,Fresenius Z. Anal. Chem. 1989,334, 27.

    Google Scholar 

  34. W. De Jonghe, D. Chakraborti, F. Adams,Anal. Chim. Acta 1980,115, 89.

    Google Scholar 

  35. A. Astruc, R. Lavigne, V. Desauziers, R. Pinel, M. Astruc,Appl. Organomet. Chem. 1989,3, 267.

    Google Scholar 

  36. G. F. Van Landeghem, P. C. D'Haese, L. V. Lamberts, M. E. De Broe,Anal. Chem. 1994,66, 216.

    Google Scholar 

  37. M. Morita, T. Uehiro, K. Fuwa,Anal. Chem. 1980,52, 351.

    Google Scholar 

  38. I. S. Krull, S. Jordan,Am. Lab. 1980,12, 21.

    Google Scholar 

  39. D. W. Hausler, L. T. Taylor,Anal. Chem. 1981,53, 1223.

    Google Scholar 

  40. D. O. Duebelbeis, S. Kapila, D. E. Yates, S. E. Manahan,J. Chromatogr. 1986,351, 465.

    Google Scholar 

  41. R. Lobiński, F. C. Adams,Trends Anal. Chem. 1993,12, 41.

    Google Scholar 

  42. B. Michalke, P. Schramel,J. Trace Elem. Electrolytes Health Dis. 1990,4, 163.

    Google Scholar 

  43. R. Cornelis,Analyst 1992,117, 583.

    Google Scholar 

  44. I. Pais, in:Environmental Sampling for Trace Analysis (B. Market, ed.), VCH, Weinheim, 1994, p. 76.

    Google Scholar 

  45. R. B. Martin, in:Aluminium in Biology and Medicine, Ciba Found. Symp. 169, Wiley, 1992, p. 5.

  46. J. Růžička, E. H. Hansen,Anal. Chim. Acta 1975,78, 145.

    Google Scholar 

  47. P. E. Gardiner, M. Stoeppler, H. W. Nürnberg, in:Trace Elem. Anal. Chem. Med. Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1984, p. 299.

    Google Scholar 

  48. H. Keirsse, J. Smeyers-Verbeke, D. Verbeelen, D. L. Massart,Anal Chim. Acta 1987,196, 103.

    Google Scholar 

  49. E. Blanco González, J. Pérez Parajón, J. I. Garcia Alonso, A. Sanz-Medel,J. Anal. At. Spectrom. 1989,4, 175.

    Google Scholar 

  50. A. Sanz-Medel, B. Fairman,Mikrochim. Acta 1992,109, 157.

    Google Scholar 

  51. L.-O. Öhman, R. B. Martin,Clin. Chem. 1994,40, 598.

    Google Scholar 

  52. K. Wróbel, E. Blanco González, A. Sanz-Medel,Trace Elem. M ed. 1993,10, 97.

    Google Scholar 

  53. K. Wróbel, E. Blanco González, A. Sanz-Medel,J. Anal. At. Spectrom. 1994,9, 281.

    Google Scholar 

  54. L. Magos,Analyst 1971,96, 847.

    Google Scholar 

  55. U. Ebbestad, N. Gundersen, T. Torgrimsen,At. Abs. Newsl. 1975,14, 142.

    Google Scholar 

  56. K. Mitani,Eisei Kagaku 1976,22, 65.

    Google Scholar 

  57. J. P. Farant, D. Brissett, L. Moncion, L. Bigras, A. Chatrand,J. Anal. Toxicol. 1981,5, 47.

    Google Scholar 

  58. J. C. Gage, J. M. Warren,Ann. Occup. Hyg. 1970,13, 115.

    Google Scholar 

  59. P. Coyle, T. Hartley,Anal. Chem. 1981,53, 354.

    Google Scholar 

  60. B. Lind, R. Body, L. Friberg,Fresenius J. Anal. Chem. 1993,345, 314.

    Google Scholar 

  61. M. Filippelli,Anal. Chem. 1987,59, 116.

    Google Scholar 

  62. E. Bulska, H. Emteborg, D. C. Baxter, W. Frech, D. Ellingsen, Y. Thomassen,Analyst 1992,117, 657.

    Google Scholar 

  63. H. W. Lakin, E. L. Kothny, in:Trace Elements in the Environment (E. L. Kothny, ed.), American Chemical Society, Washington, DC, 1973, p. 86.

    Google Scholar 

  64. J. T. Rotruck, A. L. Pope, H. E. Gauther, A. B. Swanson, D. G. Hafeman, W. G. Hoekstra,Science 1973,779, 588.

    Google Scholar 

  65. C. I. Measures, J. D. Burton,Nature 1978,273, 293.

    Google Scholar 

  66. X. Dauchy, M. Potin-Gautier, A. Astruc, M. Astruc,Fresenius J. Anal. Chem. 1994,348, 792.

    Google Scholar 

  67. P. Brätter, B. Gercken, A. Tomiak, U. Rösick, in:Trace Elem. Anal. Chem. Med. Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1988, p. 119.

    Google Scholar 

  68. A. J. Barak, S. C. Swanberg,J. Chromatogr. 1967,31, 282.

    Google Scholar 

  69. K. Kurahaschi, S. Inque, K. Toêi, Y. Shimoishi,Analyst 1980,105, 690.

    Google Scholar 

  70. A. J. Blotcky, A. Ebrahim, E. P. Rack,Anal. Chem. 1988,60, 2734.

    Google Scholar 

  71. R. M. Harrison, S. Rapsomanikis (eds.),Environmental Analysis using Chromatography Interfaced with Atomic Absorption Spectrometry, Ellis Horwood, Chichester, England, 1989.

    Google Scholar 

  72. B. Wallaeys, R. Cornelis, L. Mees, N. Lameire,Kidney Int. 1986,30, 599.

    Google Scholar 

  73. G. Devoto,Boll. Soc. Ital. Biol. Spec. 1968,44, 1251.

    Google Scholar 

  74. I. T. Urasa, S. H. Nam,J. Chromatogr. Sci. 1989,727, 30.

    Google Scholar 

  75. S. De Flora, K. E. Wetterhahn,Life Chemistry Reports, Vol. 7, Harwood, London, 1989, p. 169.

    Google Scholar 

  76. R. Cornelis, F. Borguet, S. Dyg, B. Grieprink,Mikrochim. Acta. 1992,109, 145.

    Google Scholar 

  77. B. Wallaeys, R. Cornelis, F. Belpaire, N. Lameire, in:Trace Elem. Anal. Chem. Med. Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1987, p. 451.

    Google Scholar 

  78. F. Borguet, R. Cornelis, J. Delanghe, M. C. Lambert, N. Lameire,Clin. Chim. Acta 1995, in press.

  79. B. S. Chana, N. J. Smith,Anal. Chim. Acta 1987,197, 177.

    Google Scholar 

  80. P. Weigert, A. Sappl,Fresenius Z. Anal. Chem. 1983,316, 306.

    Google Scholar 

  81. K. Dix, C. J. Cappon, T. Y. Toribara,J. Chromatogr. Sci. 1987,25, 164.

    Google Scholar 

  82. H. Faure, A. Favier, M. Tripier, J. Arnaud,Biol. Trace Elem. Res. 1990,24, 25.

    Google Scholar 

  83. P. E. Gardiner, J. M. Ottaway, G. S. Fell, R. R. Burns,Anal. Chim. Acta 1981,124, 281.

    Google Scholar 

  84. P. E. Gardiner, J. M. Ottaway,Anal. Chim. Acta 1981,124, 281.

    Google Scholar 

  85. J. Schöppenthau, L. Dunemann,Fresenius J. Anal. Chem. 1994,349, 794.

    Google Scholar 

  86. M. Takayanagi, T. Yashiro,J. Chromatogr. 1986,374, 378.

    Google Scholar 

  87. O. Nygren, C.-A. Nilsson,J. Anal. At. Spectrom. 1987,2, 805.

    Google Scholar 

  88. S. J. Bannister, Y. Chang, L. A. Sternson, A. J. Repta,Clin. Chem. 1978,24, 877.

    Google Scholar 

  89. M. Pinta, D. Barson, C. Riandey, W. Ghidalia,Spectrochim. Acta 1978,33B, 489.

    Google Scholar 

  90. W. A. DeWaal, F. J. M. J. Maessen, J. C. Kraak,J. Chromatogr. 1987,407, 253.

    Google Scholar 

  91. C. Dominici, A. Alimonti, S. Caroli, F. Petrucci, M. A. Castello,Clin. Chem. Acta 1986,158, 207.

    Google Scholar 

  92. J. M. Pérez Parajón, A. Sanz-Medel,J. Anal. At. Spectrom. 1994,9, 111.

    Google Scholar 

  93. S. C. K. Shum, R. S. Houk,Anal. Chem. 1993,65, 2972.

    Google Scholar 

  94. E. H. Larsen, G. Pritzl, S. H. Hansen,J. Anal. At. Spectrom. 1993,8, 557.

    Google Scholar 

  95. J. P. Buchet, R. Lauwerys, H. Roels,Int. Arch. Occup. Environ. Health 1981,48, 71.

    Google Scholar 

  96. A. W. Fitchett, E. H. Daughtrey Jr., P. Mushak,Anal. Chim. Acta 1975,79, 93.

    Google Scholar 

  97. R. Lauwerys, J. P. Buchet, H. Roels,Arch. Toxicol. 1979,41, 239.

    Google Scholar 

  98. J. P. Buchet, R. Lauwerys, H. Roels,Int. Arch. Occup. Environ. Health 1980,46, 11.

    Google Scholar 

  99. M. Buratti, G. Calzaferri, G. Caravelli, A. Colombi, M. Morani, V. Foa,Int. J. Environ. Anal. Chem. 1984,17, 25.

    Google Scholar 

  100. G. M. Momplaisir, J.-S. Biais, M. Quinteiro, W. D. Marshall,J. Agric. Food Chem. 1991,39, 1448.

    Google Scholar 

  101. O. Jimenez de Blas, S. V. Gonzalez, R. S. Rodriguez, J. H. Memdez,J. AOAC Int. 1994,77, 441.

    Google Scholar 

  102. X.-C. Le, W. R. Cullen, K. J. Reimer,Talanta 1994,41, 495.

    Google Scholar 

  103. X.-C. Le, W. R. Cullen, K. J. Reimer,Anal. Chim. Acta 1994,285, 277.

    Google Scholar 

  104. G. K. C. Low, G. E. Batley, S. J. Buchanan,Chromatographia 1986,22, 292.

    Google Scholar 

  105. G. K. C. Low, G. E. Batley, S. J. Buchanan,Anal. Chim. Acta. 1987,197, 327.

    Google Scholar 

  106. D. Heitkemper, J. Creed, J. Caruso, F. L. Fricke,J. Anal. At. Spectrom. 1989,4, 279.

    Google Scholar 

  107. B. S. Sheppard, J. A. Caruso, D. T. Heitkemper, K. A. Wolnik,Analyst 1992,117, 971.

    Google Scholar 

  108. I. S. Palmer, R. P. Gunsalus, A. W. Halverson, O. E. Olson,Biochem. Biophys. Acta 1969,177, 336.

    Google Scholar 

  109. K.-I. Tsunoda, K. Fuwa, in:Toxicology of Metals: Clinical and Experimental Research (S. S. Brown, Y. Kodama, eds.), Ellis Horwood, Chichester, England, 1987, p. 175.

    Google Scholar 

  110. P. Fodor, R. M. Barnes,Spectrochim. Acta 1983,38B, 229.

    Google Scholar 

  111. A. J. Blotcky, G. T. Hansen, N. Borkar, A. Ebrahim, E. P. Rack,Anal. Chem. 1987,59, 2063.

    Google Scholar 

  112. A. T. Nahapetian, V. R. Young, M. Janghorbani,Anal. Biochem. 1984,140, 56.

    Google Scholar 

  113. A. J. Blotcky, G. T. Hansen, L. R. Opelanio-Buencamino, E. P. Rack,Anal. Chem. 1985,57, 1937.

    Google Scholar 

  114. X. F. Sun, B. T. G. Ting, M. Janghorbani,Anal. Biochem. 1987,167, 304.

    Google Scholar 

  115. J. S. Blais, A. Huyghues-Despointes, G. M. Momplaisir, W. D. Marshall,J. Anal. At. Spectrom. 1991,6, 225.

    Google Scholar 

  116. F. Laborda, D. Chakraborti, J. M. Mir, J. R. Castillo,J. Anal. At. Spectrom. 1993,8, 643.

    Google Scholar 

  117. A. Campe, N. Velghe, A. Claeys,At. Abs. Newsl. 1978,17, 100.

    Google Scholar 

  118. C. E. Oda, J. D. Ingle Jr.,Anal. Chem. 1981,53, 2305.

    Google Scholar 

  119. J. W. Robinson, J. C. Wu,Spectrosc. Lett. 1985,18, 47.

    Google Scholar 

  120. M. A. Seckin, S. Aygun, O. Y. Ataman,Int. J. Environ. Anal. Chem. 1986,26, 1.

    Google Scholar 

  121. S. C. K. Shum, H. Pang, R. S. Houk,Anal. Chem. 1992,64, 2444.

    Google Scholar 

  122. G. J. Olson, F. E. Brinckman, J. A. Jackson,Int. J. Environ. Anal. Chem. 1983,15, 249.

    Google Scholar 

  123. D. Dyne, B. S. Chana, N. J. Smith, J. Cocker,Anal. Chim. Acta 1991,246, 351.

    Google Scholar 

  124. B. Neidhart, C. Tausch,Mikrochim. Acta 1992,109 137.

    Google Scholar 

  125. P. P. Chang, J. W. Robinson,Spectrosc. Lett. 1993,26, 2017.

    Google Scholar 

  126. J. C. Wu, J. W. Robinson,Spectrosc. Lett. 1986,19, 61.

    Google Scholar 

  127. J. W. M. M. Arts, J. C. M. Hafkenscheid,Clin. Chem. 1984,30, 155.

    Google Scholar 

  128. P. Brätter, B. Gercken, U. Rösick, A. Tomiak, in:Trace Elem. Anal. Chem. Med. Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1988, p. 145.

    Google Scholar 

  129. L. A. Hanson, F. Jalil, S. R. Kahn, M. Hahn-Zoric, in:Composition and Physiological Properties of Human Milk (J. Schaub, ed.), Elsevier, Amsterdam, 1985, p. 297.

    Google Scholar 

  130. G. V. Iyengar,Biol. Trace Elem. Res. 1987,12, 263.

    Google Scholar 

  131. P. Van Dael, H. Deelstra, G. Vlaemynck, R. Van Renterghem, in:Trace Elem. Anal. Chem. Med. Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1988, p. 136.

    Google Scholar 

  132. P. B. Moser-Veillon, A. R. Mangels, K. Y. Patterson, C. Veillon,Analyst 1992,117, 559.

    Google Scholar 

  133. H. E. Heilmeier, P. Schramel, G. A. Drasch, E. Kretschmer, K. H. Summer, in:Trace Elem. Anal. Chem. Med. and Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1987, p. 495.

    Google Scholar 

  134. B. Michalke, in:Trace Elem. Anal. Chem. Med. and Biol. (P. Brätter, P. Schramel, eds.), de Gruyter, Berlin, 1993, p. 397.

    Google Scholar 

  135. B. Michalke, D. C. Münch, P. Schramel,Fresenius J. Anal. Chem. 1992,344, 306.

    Google Scholar 

  136. B. Michalke,Fresenius J. Anal. Chem. 1994,350, 2.

    Google Scholar 

  137. J. C. Vidal, R. B. Vinao, J. R. Castillo,Electroanalysis (N.-Y.) 1992,4, 653.

    Google Scholar 

  138. F. Macášek, P. Gerhart,J. Radioanal. Nucl. Chem., Lett. 1994,186, 9.

    Google Scholar 

  139. F. Macášek, P. Gerhart, A. Malovíková,J. Radioanal. Nucl. Chem., Lett. 1994,186, 99.

    Google Scholar 

  140. J. G. Parks, R. A. Hussain, N. F. Olivieri, D. M. Templeton,J. Lab. Clin. Med. 1993,122, 36.

    Google Scholar 

  141. H. M. Barbour,Ann. Clin. Biochem. 1991,28, 150.

    Google Scholar 

  142. F. Lagerlof, S. Matsuo,Clin. Chim. Acta 1991,198, 175.

    Google Scholar 

  143. S. Matsushita,J. Chromatogr. 1984,312, 327.

    Google Scholar 

  144. J. M. C. Gutteridge,Clin. Sci. 1992,82, 315.

    Google Scholar 

  145. X. Xue, S. Chen,Fenxi Huaxue 1987,15, 1099.

    Google Scholar 

  146. A. L. Caldini, C. Orlando, T. Barni, G. Messeri, M. Pazzagli, E. Baldi, M. Serio,Clin. Chem. 1986,32, 153.

    Google Scholar 

  147. M. Gavella,Clin. Chem. 1988,34, 1605.

    Google Scholar 

  148. W. Buchberger, G. Rieger,J. Chromatogr. 1989,482, 407.

    Google Scholar 

  149. R. Giordano, S. Costantini, I. Vernillo, M. Rizzica,At. Spectrosc. 1983,4, 157.

    Google Scholar 

  150. F.-M. Matysik, G. Werner,Analyst 1993,118, 1523.

    Google Scholar 

  151. P. Dumortier, P. De-Vuyst, J. C. Yernault,Scanning Microsc. 1989,3, 1207.

    Google Scholar 

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  1. Arabinda K. Das & Ruma Chakraborty

    Present address: Department of Chemistry, University of Burdwan, 713 104, Burdwan, India

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  1. Department of Analytical Chemistry, University of Valencia, 50, Doctor Moliner St., E-46100, Burjassot, Valencia, Spain

    Arabinda K. Das, Ruma Chakraborty, M. Luisa Cervera & Miguel de la Guardia

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Das, A.K., Chakraborty, R., Luisa Cervera, M. et al. Metal speciation in biological fluids — a review. Mikrochim Acta 122, 209–246 (1996). https://doi.org/10.1007/BF01245784

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