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The effect of mercurials on the integrity of the poliovirion

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Summary

Mercuric ions and simple organic mercury derivatives interact with poliovirions in borate buffers. This interaction leads to the following sequence of events: loss of virus infectivity, release of viral RNA in an infectious form and, probably, disintegration of the viral capsid into smaller protein fragments.

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Authors and Affiliations

  1. Division of Cell Biology, Department of Medical Microbiology, Uppsala University, Uppsala, Sweden

    Lennart Philipson

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  1. Lennart Philipson
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Additional information

Dedicated to the Honor of the 60th birthday of ProfessorSven Gard.

This work was supported by grants from the U. S. Public Health Service (AI-04193-03), the Swedish Medical Research Council (Y 420) and the Damon Runyon Memorial Fund for Cancer Research.

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Philipson, L. The effect of mercurials on the integrity of the poliovirion. Archiv f Virusforschung 17, 472–480 (1965). https://doi.org/10.1007/BF01241203

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  • DOI: https://doi.org/10.1007/BF01241203

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