Abstract
Mercury(II) oxide has been reacted with D-gluconic acid (Gl) in an aqueous solution at a molar ratio of the reagents equal to 1: 2 to obtain mercury complex Hg2(C6H11O7)2 (I). The product isolated has been studied by elemental analysis, molar conductivity, IR, electronic, and NMR spectroscopy, and X-ray diffraction. The data obtained indicate that the compound contains the binuclear cation (Hg2)2+. It has been found that the complex has a chelate structure. Each mercury atom in I is connected with two oxygen atoms: one from the carbon atom of the carboxyl group and another from the hydroxyl group at the second carbon atom in the Gl molecule. Two gluconate ions in the complex have different configurations. Toxicity of I is ten times less than the toxicity of the starting mercury compound. Reacting Gl with the oxide of divalent mercury in an aqueous medium decreased he toxicity of the mercury compound due to its reduction to a formally monovalent state. The results can be useful for studying mercury detoxification and the application of Gl.
Similar content being viewed by others
References
S. Dinc, M. Kara, M. Oqut, et al., Hacettepe J. Biol. Chem. 45, 603 (2017). doi https://doi.org/10.15671/HJBC.2018.203
A. Pandey, S. Negi, and C. R. Soccol, Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial Products (Elsevier, 2016).
S. Ramachandran, P. Fontanille, A. Pandey, and C. Larroche, Food Technol. Biotechnol 44, 185 (2006). doi https://doi.org/10.1007/s12010-008-8209-0
Y. Wang, N. Nomura, M. Zeniya, et al., J. Med. Dent. Sci. 65, 35 (2018). doi https://doi.org/10.11480/jmds.650105
M. K. Trivedi, N. Dixit, P. Panda, et al., J. Pharm. Anal. 7, 332 (2017). doi https://doi.org/10.1016/j.jpha.2017.03.006
X. Chen, Z. Yang, and P. X. Metric, Am. J. Emerg. Med. 35, 1209e1 (2017). doi https://doi.org/10.1016/j.ajem.2017.04.006
R. M. P. I. Rajakaruna, I. R. Ariyarathna, and D. N. Karunaratne, Ceylon J. Sci. 45, 3 (2016). doi https://doi.org/10.4038/cjs.v45i2.7384
Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Ed. by P. Lanzkowsky, J. Lipton, and J. Fish, (Elsevier, 2016).
H. Hemila and E. Chalker, Cochrane Database of Systematic Reviews, No. 9, CD012808 (2017). doi https://doi.org/10.1002/14651858.CD012808
M. M. Elseweidy, A.-M. A. Ali, N. Z. Elabidine, and M. Mursey, Biomed. Pharmacother. 95, 317 (2017). doi https://doi.org/10.1016/j.biopha.2017.08.081
Ya. A. Fialkov and N. G. Peryshkina, Zh. Neorg. Khim. 2, 749 (1957).
S. J. Angyal, Pure Appl. Chem. 35, 1351 (1973). doi https://doi.org/10.1351/pac197335020131
J. F. Ashtan and W. F. Pickering, Aust. J. Chem. 23, 1071 (1976). doi https://doi.org/10.1071/CH9701367
M. A. Amin and M. S. Refat, Arabian J. Chem. 6, 165 (2013). doi https://doi.org/10.1016/j.arabjc.2010.09.030
I. G. Konkina, S. P. Ivanov, Yu. I. Murinov, et al., Pharm. Chem. J. 36, 18 (2002). doi https://doi.org/10.1023/A:101579262
I. G. Konkina, S. P. Ivanov, Yu. I. Murinov, et al., Russ. J. Inorg. Chem. 48, 880 (2003).
O. A. Knyazeva, S. I. Urazaeva, I. G. Konkina, et al., Kazan. Med. Zh. 99, 255 (2018). doi https://doi.org/10.17816/KMJ2018-255
J. E. Gray, P. M. Theodorakos, D. L. Fey, and D. P. Krabbenhoft, Environ. Geochem. Health 37, 35 (2015). doi https://doi.org/10.1007/s10653-014-9628-1
S. Wang, T. Zhong, D. Chen, and X. Zhang, Sustainability, No. 8, 795 (2016). doi https://doi.org/10.3390/su8080795
L. V. Lukovnikova, G. I. Sidorin, L. A. Alikbaeva, and A. V. Galoshina, Toksikol. Vestn., No. 5, 2 (2017).
R. A. Kiper, Environmental Effects and Toxicology of Mercury. http://chemister.ru/Toxicology/ecologija-i-toxicologija-rtuti.htm
G. Genchi, M. S. Sinicropi, A. Carocci, et al., Int. J. Environ. Res. Public Health 14, 74 (2017). doi https://doi.org/10.3390/ijerph14010074
A. G. Peregrina-Châvez, M.-del-R. Ramírez-Galindo, R. Chávez-Martínez, et al., Int. J. Environ. Res. Public Health 15, 657 (2018). doi https://doi.org/10.3390/ijerph15040657
L. E. Shinetova and S. A. Bekeeva, Vestn. Kazakhskogo Nat. Med. Univ., No. 1, 370 (2017).
S. A. Hassan and L. C. Abbott, J. Vet. Anat. 10 (1), 49 (2017).
P. Morcillo, M. A. Esteban, and A. Cuesta, AIMS Environ. Sci. 4, 386 (2017). doi https://doi.org/10.3934/environ-sci.2017.3.386
G. Bjørklund, J. Mutter, and J. Aaseth, Arch. Toxicol 91, 3787 (2017). doi https://doi.org/10.1007/s00204-017-2100-0
J. Aaseth, M. S. Skaug, Y. Cao, and O. Andersen, J. Trace Elem. Med. Biol. 31, 260 (2015). doi https://doi.org/10.1016/j.jtemb.2014.10.001
Y. Cao, M. A. Skaug, O. Andersen, and J. Aaseth, J. Trace Elem. Med. Biol. 31, 188 (2015). doi https://doi.org/10.1016/j.jtemb.2014.04.010
J. Aaseth, O. P. Ajsuvakova, A. V. Skalny, et al., Coord. Chem. Rev. 358, 1 (2018). doi https://doi.org/10.1016/j.ccr.2017.12.011
H. A. Tajmir-Reahi, Can. J. Chem. 67, 651 (1989). doi https://doi.org/10.1139/v89-098
G. M. Escandar, Salas Peregrin J.M., Sierra M.G. et al., Polyhedron 15, 2251 (1996). doi https://doi.org/10.1016/0277-5387(95)00478-5
G. Svehla and C. L. Wilson, Comprehensive Analytical Chemistry, 6: Analytical Infrared Spectroscopy, Ed. by G. Svehla (Elsevier, 1976).
I. G. Konkina, Z. A. Starikova, D. V. Lybeckyi, and Yu. I. Murinov, Russ. J. Phys. Chem. 79, 1987 (2005).
G. M. Sheldrick, SHELXTL 5.10 (Bruker, Madison. WI, USA, 1998).
K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds (Interscience, New York, 1986).
L. A. Kazitsyna and N. B. Kupletskaya, Application of UV, IR, NMR, and Mass Spectroscopy in Organic Chemistry (Moscow Univ. Press, Moscow, 1979) [in Russian].
N. V. Somov, F. F. Chausov, R. M. Zakirova, et al., Russ. J. Coord. Chem. 44, (2018). doi https://doi.org/10.7868/SO132344X18010036
Seo S. Sujin, H. Ju, and S. Kim, Inorg. Chem. 55, 11028 (2016). doi https://doi.org/10.1021/acs.inorgchem.6b01583
J. Ha, X. Zhao, R. Yu, et al., Appl. Geochem. 78, 211 (2017). doi https://doi.org/10.1016/j.apgeochem.2016.12.017
E. Berl’-Lunge, Chemicotechnical Characterization Methods (Khimteoret, Leningrad, 1941), Vol. 3 [in Russian].
N. C. Panagiotopoulos and W. C. Hamilton, Acta Crystallogr., Sect. B 30, 1421 (1974). doi https://doi.org/10.1107/S0567740874005012
Poisons and Antidotes. Dose of Poison. Toxicity Characteristics. http://www.kristallikov.net/page53.html.
M. D. Mashkovskii, Medicines: A Manual for Physicians (Novaya Volna, Moscow, 2011).
Safety Data Sheet in accordance with Regulation (EU) no. 1907/2006. Mercury(II) Acetate. http://www.mer-ckrnillipore.com/…/web.
Material Safety Data Sheet Mercuric oxide MSDS. http://www.sciencelab.com/msds.php?msdsId=9924619.
Author information
Authors and Affiliations
Corresponding author
Additional information
Russian Text © I.G. Konkina, S.P. Ivanov, Yu.I. Murinov, 2019, published in Zhurnal Neorganicheskoi Khimii, 2019, Vol. 64, No. 2, pp. 165–171.
Rights and permissions
About this article
Cite this article
Konkina, I.G., Ivanov, S.P. & Murinov, Y.I. Binuclear Mercury(I) Complex with D-Gluconic Acid. Russ. J. Inorg. Chem. 64, 201–206 (2019). https://doi.org/10.1134/S0036023619020116
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0036023619020116