Summary
HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary ‘protective’ role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Nerup, J., Cathelineau, C., Seignalet, J., Thomsen, M.: In: HLA and disease. Dausset, J., Svejgaard, A. (Eds.), pp. 149–167. Cophenhagen: Munksgaard 1976
Cudworth, A. G.: Type 1 diabetes mellitus. Diabetologia14, 281–291 (1978)
Thomsen, M., Platz, P., Andersen, O. O., Christy, M., Lyngs0e, J., Nerup, J., Rasmussen, K., Ryder, L. P., Nielsen, L. S., Svejgaard, A.: MLC typing in juvenile diabetes mellitus and idiopathic Addison's disease. Transplant. Rev.22, 120–125 (1975)
Cudworth, A. G., Festenstein, H.: HLA genetic heterogeneity in diabetes mellitus. Br. Med. Bull.34, 285–289 (1978)
Cudworth, A. G., Bottazzo, G. F., Doniach, D.: Genetic and immunological factors in Type 1 diabetes mellitus. In: Immunology of diabetes. Irvine, W. J. (Ed.). Edinburgh: Teviot Publications 1979
Nerup, J., Christy, M., Kromann, H., Andersen, O. O., Platz, P., Ryder, L. P., Thomsen, M., Svejgaard, A.: Genetic susceptibility and resistance to insulin dependent diabetes mellitus (IDDM). In: Immunology of diabetes. Irvine, W. J. (Ed.). Edinburgh: Teviot Publications 1979
Festenstein, H., Demant, P.: In: HLA and H-2. Festenstein, H., Demant, P. (Eds.), p. 169. London: Edward Arnold 1978
Rubinstein, P., Suciu-Foca, N., Nicholson, J. F.: Genetics of juvenile diabetes mellitus. A recessive gene closely linked to HLA D with 50 per cent penetrance. N. Engl. J. Med.297, 1036–1040 (1977)
Bodmer, W. F., Batchelor, J. R., Bodmer, J. B., Festenstein, H. (Eds.): Histocompatibility testing 1977, pp. 85–145. Copenhagen: Munksgaard 1977
Mendel, N. R., Guppy, D., Bodmer, W. F., Festenstein, H.: In: Histocompatibility testing 1977. Bodmer, W. F., Batchelor, J.R., Bodmer, J. B., Festenstein, H. (Eds.), p. 90. Copenhagen: Munksgaard 1977
Ryder, L. P., Thomsen, M., Platz, P., Svejgaard, A.: In: Histocompatibility testing 1975. Kissmeyer-Nielsen, F. (Ed.), p. 557. Copenhagen: Munksgaard 1975
Woolf, B.: On estimating the relation between blood groups and disease. Ann. Hum. Genet.19, 251–253 (1955)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sachs, J.A., Cudworth, A.G., Jaraquemada, D. et al. Type 1 diabetes and the HLA-D locus. Diabetologia 18, 41–43 (1980). https://doi.org/10.1007/BF01228300
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01228300