Summary
The ultrastructure of the islets of Langerhans was studied in seven human neonates. Out of the five cell types, described by the same authors in the islets of adults, four were also found in the islets of neonates: B cells, A cells, type III cells and type IV cells. Type III cells were far more numerous in the newborn in contrast with type V cells which were not found. In comparison with the islets of adults those of neonates showed a considerably higher number of pale granules in the B cells and a complete absence of fat vacuoles in all four cell types.
Résumé
L'ultrastructure des îlots de Langerhans a été étudiée sur sept pancréas de nouveau-nés. Quatre des cinq types cellulaires que les auteurs ont décrits dans les îlots d'adultes ont été retrouvés chez le nouveau-né: cellules B, cellules A, cellules du type III et cellules du type IV. Les cellules du type V font défaut chez le nouveau-né qui, par contre présente une plus grande abondance de cellules du type III. D'autres différences notables avec l'adulte sont présentes chez le nouveau-né: une proportion nettement plus grande de grains pâles dans les cellules B et l'absence de vacuoles graisseuses dans les cellules insulaires de tous types.
Zusammenfassung
Die Ultrastruktur der Langerhans' sehen Inseln wurde in den Pankreata von 7 Neugeborenen untersucht. Vier der fünf Zelltypen, welche die Autoren in des Inseln Erwachsener beschrieben hatten, konnten auch beim Neugeborenen gefunden werden: B-Zellen, A-Zellen, Typ III- und Typ IV-Zellen. Die Typ V-Zellen fehlen beim Neugeborenen. Dieser hat dagegen mehr Zellen vom Typ III. Noch andere wichtige Unterschiede lassen sich beim Neugeborenen finden: eine deutlich größere Menge blasser Granula in den B-Zellen, sowie das völlige Fehlen von Fett-Vacuolen in den Inselzellen aller Typen.
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Deconinck, J.F., Van Assche, F.A., Potvliege, P.R. et al. The ultrastructure of the human pancreatic islets. Diabetologia 8, 326–333 (1972). https://doi.org/10.1007/BF01218493
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DOI: https://doi.org/10.1007/BF01218493