Abstract
The amino acid composition of proteins from liver microsomes has been studied in rats and in human subjects with normal liver, with obstructive jaundice or liver cirrhosis. The pattern of the amino acid composition of microsomes appeared to be species-specific. Phenylalanine, threonine, serine, proline, histidine and [aspartic acid plus asparagine] were increased, while alanine, tyrosine, glycine and arginine were decreased in the human compared to the rat microsomes. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in leucine and phenylalanine could be noticed, while in the case of liver cirrhosis amino acid composition was markedly changed.
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References
Argos, P., Rao, J. K. M. and Margrave, P. A. (1982)Eur. J. Biochem. 128:565–575.
Atkin, G. E. and Ferdinand, W. (1970)Analyt. Biochem. 38:313–329.
Atkin, G. E. and Ferdinand, W. (1971)Analyt. Biochem. 62:373–381.
Balasingam, K. and Ferdinand, W. (1970)Biochem. J. 118:15–23.
Benga, Gh. (1973)Stud. Cerc. Biochim. 16:251–260.
Benga, Gh. (1974)Stud. Cerc. Biochim. 17:123–135.
Benga, Gh. (1975)Stud. Cerc. Biochim. 18:88–91.
Benga, Gh. ed. (1985)Structure and Properties of Cell Membranes, vol. 1–3, CRC, Boea Raton.
Benga, Gh. (1989) In:Molecular Basis of Membrane-Associated Diseases (eds: Azzi, A., Drahota, Z. and Papa, S.) Springer Verlag, Berlin, Heidelberg, 285–302.
Benga, Gh., and Mure¢an, L. (1974)Biochem. Med. 10:131–367.
Benga, Gh. and Borza, V. (1975)Arch. Biochem. Biophys. 169:354–357.
Benga, Gh. and Ferdinand, W. (1977)Int. J. Biochem. 8:17–20.
Benga, Gh. and Holmes, R. P. (1984)Prog. Biophys. Mol. Biol. 43:195–257.
Benga, Gh., Tarmure, C. and Hodârnau, A. (1971)Enzyme 12:574–577.
Benga, Gh., Muresan, L., Hodârnau, A. and Dancea, S. (1972)Biochem. Med. 6:508–521.
Benga, Gh., Petrescu, I., Tarmure, C. and Pop, V. I. (1980)Rev. Roum. Biol. 25:147–154.
Benga, Gh., Porutiu, D., D., Hodârnau, A. and Ferdinand, W. (1992)Comp. Biochem. Physiol. 102B:123–128.
Benga, Gh., Hodârnau, A., Böhm, B., Borza, V., Tilinca, R., Dancea, S. and Petrescu, I. (1978)Eur. J. Biochem. 84:625–633.
Benga, Gh., Hodârnau, A., Tilinca, R., Porutiu, D., Dancea, S., Pop, V. I. and Wrigglesworth, J. (1979)J. Cell Sci. 35:417–429.
Benga, Gh., Pop, V. I., Ionescu, M., Hodârnau, A., Tilinca, R. and Frangopol, P. T. (1983)Biochim. Biophys. Acta 750:194–199.
Benga, Gh., Hodârnau, A., Tilinca, R., Borza, V. and Ferdinand, W. (1991)Biosci. Rep. 11:95–100.
Blouin, A., Bolender, R. P. and Weibel, E. R. (1977)J. Cell Biol. 72:441–445.
Dallner et al (1966)J. Cell Biol. 31:181–194.
Engelman, D. M., Steitz, A. T. and Goldman, A. (1986)Ann. Rev. Biophys. Chem. 15:321–353.
Fleischer, S. and Fleischer, B. (1977) In:Membrane Alterations as Basis of Liver Injury (eds: Popper, H., Bianchi, L. and Reuter, W.) MTP Press Ltd., Lancaster, 31–48.
Lodish, H. F. (1988)Trends Biochem. Sci. 13:332–334.
McCrea, P. D., Engelman, D. M. and Popot, J. L. (1988)Trends Biochem. Sci. 13:289–290.
Rouser, E., Nelson, G. J., Fleischer, S. and Simon, G. (1968) In:Biological Membranes. Physical Fact and Function (ed: Chapman, D.) vol. 1, Academic Press, New York, London, 5–69.
Schmidt, E. and Schmidt, F. W. (1970)Enzymol. Biol. Clin. 11:67–129.
Toader, C., Acalovschi, I., Toader, I., Manta, I., Hodârnau, A. and Benga, Gh. (1976)Enzyme 21:232–242.
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Benga, G., Ferdinand, W. Amino acid composition of rat and human liver microsomes in normal and pathological conditions. Biosci Rep 15, 111–116 (1995). https://doi.org/10.1007/BF01200145
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DOI: https://doi.org/10.1007/BF01200145