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Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats

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Bioscience Reports

Abstract

(−)-Epicatechin has previously been suggested to rapidly reverse alloxan diabetes in rats. We have assessed the therapeutic value of the compound in two further animal models of insulin-dependent diabetes mellitus, namely streptozotocin - diabetic rats and the spontaneously diabetic BB/E rat . There was no indication of a reversal of established diabetes in either the streptozotocin-diabetic or the spontaneously diabetic BB/E rats. Moreover, epicatechin also failed to halt the progression of the disease in prediabetic BB/E rats. Earlier claims of the potential use of epicatechin as an antidiabetic agent must therefore be treated with some caution.

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Authors and Affiliations

  1. Metabolic Unit, Western General Hospital, Edinburgh, U.K.

    A. J. bone, D. Brown & W. Smith

  2. Department of Physiology, Queen Elizabeth College, W8 7AH, London, U.K.

    C. S. T. Hii & S. L. Howell

Authors
  1. A. J. bone
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  2. C. S. T. Hii
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  3. D. Brown
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  4. W. Smith
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  5. S. L. Howell
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bone, A.J., Hii, C.S.T., Brown, D. et al. Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats. Biosci Rep 5, 215–221 (1985). https://doi.org/10.1007/BF01119590

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  • DOI: https://doi.org/10.1007/BF01119590

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