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Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog

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Abstract

The interaction between motilin and somatostatin on gastrointestinal motor activity was studied in fasted, unanesthetized dogs. Contractions of the stomach, duodenum, jejunum, and ileum were recorded with extraluminal strain gage force transducers. Motilin initiated a pattern of contractile activity which closely resembled phase III of the interdigestive motor complex. Somatostatin delayed the onset of the motilin response and reduced motor activity in the stomach and the jejunum. During somatstatin infusion the motilin-induced contractile pattern did not migrate to the jejunum. The cycle of natural interdigestive motor complexes was also interrupted by somatostatin. Somatostatin alters natural and motilin-induced interdigestive migrating motor complexes of the canine gastrointestinal tract.

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Authors and Affiliations

  1. Department of Surgery, University of Maryland, School of Medicine, 22 South Greene Street, Box 85, 21201, Baltimore, Maryland

    Herbert S. Ormsbee III PhD (Assistant Professor of Surgery), Stewart L. Koehler Jr MD & Gordon L. Telford MD

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  1. Herbert S. Ormsbee III PhD
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  2. Stewart L. Koehler Jr MD
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  3. Gordon L. Telford MD
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Supported by a grant from the Bressler Research Fund, University of Maryland, School of Medicine.

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Ormsbee, H.S., Koehler, S.L. & Telford, G.L. Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog. Digest Dis Sci 23, 781–788 (1978). https://doi.org/10.1007/BF01079786

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